Las lesiones condrales y osteondrales afectan a sectores del cartílago articular. Producen dolor, inflamación e impotencia funcional que evolucionan a osteoartritis. Los factores de crecimiento presentes en el plasma rico en plaquetas (PRP) son señales bioquímicas capaces de modificar las respuestas ...
Abstract Objective To evaluate clinically and radiologically the results of the treatment of chondral lesions using collagen membrane - autologous matrix-induced chondrogenesis (AMIC). Methods This is a series of observational cases, in which 15 patients undergoing AMIC were analyzed. The clinical eval...
ABSTRACT Objectives: To evaluate the clinical and functional results of patients diagnosed with full-thickness chondral defects on symptomatic knees who underwent a biological repair technique using autologous matrix-induced chondrogenesis. Methods: Seven patients who underwent surgical treatment due t...
OBJECTIVES: Articular cartilage is vulnerable to injuries and undergoes an irreversible degenerative process. The use of amniotic fluid mesenchymal stromal stem cells for the reconstruction of articular cartilage is a promising therapeutic alternative. The aim of this study was to investigate the chondro...
Agrecanos/metabolismo,
Líquido Amniótico,
Técnicas de Cultivo de Célula/métodos,
Diferenciación Celular,
Condrocitos/citología,
Condrogénesis,
Colágeno Tipo II/análisis,
Expresión Génica,
Células Madre Mesenquimatosas/citología,
Factor de Transcripción SOX9/metabolismo,
Factor de Crecimiento Transformador beta3/metabolismo
Abstract Small ruminant lentiviruses isolated from peripheral blood leukocytes and target organs can be propagated in vitro in fibroblasts derived from goat synovial membrane cells. These cells are obtained from tissues collected from embryos or fetuses and are necessary for the establishment of the fibr...
Lentivirus/fisiología,
Células Madre Mesenquimatosas/virología,
Adipogénesis,
Biomarcadores,
Técnicas de Cultivo de Célula,
Diferenciación Celular,
Células Cultivadas,
Condrogénesis,
Efecto Citopatogénico Viral,
Cabras,
Inmunofenotipificación,
Técnicas In Vitro,
Células Madre Mesenquimatosas/citología,
Células Madre Mesenquimatosas/metabolismo,
Células Madre Mesenquimatosas/patología,
Osteogénesis,
Replicación Viral,
Cordón Umbilical/citología
This study was undertaken to clarify the role and mechanism of pyruvate dehydrogenase kinase isoform 2 (PDK2) in chondrogenic differentiation of mesenchymal stem cells (MSCs). MSCs were isolated from femurs and tibias of Sprague-Dawley rats, weighing 300-400 g (5 females and 5 males). Overexpression and ...
The mammalian Wharton's jelly of umbilical cord (WJUC) is a promising source of multipotent cells, providing advantages due to ethical implications, ease of collection and the absence of teratomas in pre-clinical trials. Ovine multipotent cells have already been isolated from various tissues, however the...
Bone is a unique tissue which could regenerate completely after injury rather than heal itself with a scar. Compared with other tissues the difference is that, during bone repairing and regeneration, after the inflammatory phase the mesenchymal stem cells (MSCs) are recruited to the injury site and diffe...
La ingeniería tisular se plantea como tratamiento ideal para la regeneración de tejidos con la utilización de andamiajes, células madres y factores de crecimiento. Las células madres de origen gingival plantean ventajas de obtención, mientras que el OPLA 3D permite cultivos de alta densidad celular...
Encía/citología,
Ingeniería de Tejidos/métodos,
Células del Tejido Conectivo/citología,
Células Madre Mesenquimatosas/citología,
Inmunofenotipificación,
Diferenciación Celular,
Supervivencia Celular,
Osteogénesis,
Polímeros/química,
Ácido Láctico/química,
Ensayo de Materiales,
Andamios del Tejido,
Proliferación Celular,
Células Cultivadas,
Condrogénesis
Amelogenin is one of the enamel matrix proteins secreted by ameloblasts during enamel formation in tooth development. Recent studies showed that the amelogenin is expressed in chondrocyte. Lysosome-associated membrane proteins (LAMPs) have been identified as binding partner proteins to amelogenin and it ...
