LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

PDK2 promotes chondrogenic differentiation of mesenchymal stem cells by upregulation of Sox6 and activation of JNK/MAPK/ERK pathway

Wang, H; Shan, XB; Qiao, YJ.

Braz. j. med. biol. res; 50 (2), 2017

This study was undertaken to clarify the role and mechanism of pyruvate dehydrogenase kinase isoform 2 (PDK2) in chondrogenic differentiation of mesenchymal stem cells (MSCs). MSCs were isolated from femurs and tibias of Sprague-Dawley rats, weighing 300-400 g (5 females and 5 males). Overexpression and ...

Diferenciación Celular, Condrogénesis/fisiología, Proteínas Quinasas JNK Activadas por Mitógenos/fisiología, Sistema de Señalización de MAP Quinasas/fisiología, Células Madre Mesenquimatosas/fisiología, Proteínas Serina-Treonina Quinasas/fisiología, Ratas Sprague-Dawley, Factores de Transcripción SOXE/fisiología, Activación Transcripcional, Regulación hacia Arriba

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Using mesenchymal stem cells as a therapy for bone regeneration and repairing

Bone is a unique tissue which could regenerate completely after injury rather than heal itself with a scar. Compared with other tissues the difference is that, during bone repairing and regeneration, after the inflammatory phase the mesenchymal stem cells (MSCs) are recruited to the injury site and diffe...