LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

The liver injury following ischemia and reperfusion is worse in experimental knockout heterozygote mouse model for expression of connexin 43

Trevisan, Alexandre Maximiliano; Cogliati, Bruno; Homem, Adriana Ribeiro; Aloiav, Thiago Pinheiro Arrais; Aquino Neto, Nelson de; Moreira, Jairo Marques; Reno, Leonardo da Cruz; Naumann, Alexandre Moulin; Galvão, Flavio Henrique Ferreira; Andraus, Wellington; D'Albuquerque, Luiz Augusto Carneiro.

Acta cir. bras; 34 (10), 2019

Abstract Purpose: To evaluate that Connexin (Cx43) plays a role in lesions after hepatic ischemia/reperfusion (IR) injury. Methods: We use Cx43 deficient model (heterozygotes mice) and compared to a wild group. The groups underwent 1 hour ischemia and 24 hours reperfusion. The heterozygote genotype was...

Alanina Transaminasa/análisis, Aspartato Aminotransferasas/análisis, Conexina 43/análisis, Conexina 43/deficiencia, Modelos Animales de Enfermedad, Técnicas de Genotipaje, Hígado/irrigación sanguínea, Hígado/patología, Ratones Noqueados, Necrosis, Reacción en Cadena de la Polimerasa, Valores de Referencia, Daño por Reperfusión/metabolismo, Daño por Reperfusión/patología, Factores de Tiempo, gamma-Glutamiltransferasa/análisis

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Gestational Protein Restriction Increases Cardiac Connexin 43 mRNA levels in male adult rat offspring

Abstract Background: The dietary limitation during pregnancy influences the growth and development of the fetus and offspring and their health into adult life. The mechanisms underlying the adverse effects of gestational protein restriction (GPR) in the development of the offspring hearts are not well u...