DNA removal from a purification process of recombinant hepatitis B surface antigen
Electron. j. biotechnol; 10 (1), 2007
We studied the capacity of an API-rHBsAg purification process to eliminate DNA contamination from yeast-host cell. Firstly, was demonstrated consistency of manufacturing purification process to remove DNA, from (3.9 + - 1.9)108 pg/dose in starting material to (3.4 + - 1.6) pg/dose, equivalent to 8.2 log ...