Exposure to normobaric hyperoxia (NH) is known to increase the production of reactive oxygen species (ROS) by mitochondria. The present study was designed to examine mitochondrial ultrastructure morphological changes in the cortical brainin relation to glutathione peroxidase (GPX) activity and free radic...
Hiperoxia/patología,
Corteza Cerebral/patología,
Corteza Cerebral/ultraestructura,
Glutatión Peroxidasa/metabolismo,
Especies Reactivas de Oxígeno,
Especies de Nitrógeno Reactivo,
Mitocondrias/patología,
Corteza Cerebral/enzimología,
Análisis de Varianza,
Mitocondrias/ultraestructura,
Ratas Wistar
ABSTRACT Corticobasal degeneration (CBD) was originally described as a distinct clinicopathological entity in 1967. Since then, different phenotypic presentations have emerged as possible manifestations of CBD histopathological findings. In addition, pathophysiological findings and the molecular basis ha...
Afasia/patología,
Atrofia/patología,
Ganglios Basales/patología,
Corteza Cerebral/patología,
Disfunción Cognitiva/diagnóstico,
Disfunción Cognitiva/patología,
Demencia/diagnóstico,
Demencia/patología,
Diagnóstico Diferencial,
Lenguaje,
Enfermedades Neurodegenerativas/diagnóstico,
Enfermedades Neurodegenerativas/patología,
Enfermedades Neurodegenerativas/psicología,
Pruebas Neuropsicológicas,
Escalas de Valoración Psiquiátrica,
Habla/fisiología
La corteza insular es uno de los componentes de la zona paralímbica que presenta conexiones con áreas corticales y subcorticales. El estudio en personas viviendo con VIH (PVVIH), donde la apatía es frecuente, la implicó como modulador de respuesta emocional y ejecutiva. El objetivo es describir morfo...
Rabies is a lethal disease caused by a neurotropic virus that produces inconspicuous morphological changes hardly observable with conventional histopathology. The fatal outcome caused by rabies could be attributed to specific biochemical changes that severely impact neuronal function. The neuronal nuclea...
ABSTRACT PURPOSE: To investigate the protective effect of Bg on cisplatin (CP)-induced neurotoxicity in rats. METHODS: Twenty eight rats were randomly distributed into four groups. The first group was kept as a control. In the second group, CP was given at the single dose of 7 mg/kg intraperitoneally....
Antineoplásicos/efectos adversos,
Encefalopatías/prevención & control,
Encéfalo/efectos de los fármacos,
Cisplatino/efectos adversos,
beta-Glucanos/farmacología,
Antineoplásicos/metabolismo,
Encéfalo/metabolismo,
Encéfalo/patología,
Encefalopatías/inducido químicamente,
Encefalopatías/patología,
Corteza Cerebral/efectos de los fármacos,
Corteza Cerebral/metabolismo,
Corteza Cerebral/patología,
Cisplatino/metabolismo,
Modelos Animales,
Estrés Oxidativo,
Sustancias Protectoras/farmacología,
Distribución Aleatoria,
Ratas Sprague-Dawley
The timing and mechanisms of protection by hyperbaric oxygenation (HBO) in hypoxic-ischemic brain damage (HIBD) have only been partially elucidated. We monitored the effect of HBO on the mitochondrial function of neuronal cells in the cerebral cortex of neonatal rats after HIBD. Neonatal Sprague-Dawley r...
Animales Recién Nacidos,
Corteza Cerebral/patología,
Corteza Cerebral/fisiopatología,
Modelos Animales de Enfermedad,
Oxigenoterapia Hiperbárica/métodos,
Hipoxia-Isquemia Encefálica/patología,
Hipoxia-Isquemia Encefálica/fisiopatología,
Hipoxia-Isquemia Encefálica/terapia,
Mitocondrias/patología,
Mitocondrias/fisiología,
Neuronas/patología,
Neuronas/fisiología,
Distribución Aleatoria,
Ratas Sprague-Dawley,
Factores de Tiempo
Central nervous system tumors are a major cause of morbidity and mortality. Themain pathology involved is brainmetastases, followed by intrinsic gliomas. In nearly all cases, surgery is the initial and most important measure to change natural course of disease. In brain metastases and meningiomas, gross ...
The microtubule-associated protein MAP-2 is an integral part of the cytoskeleton and plays an important role in neural morphogenesis. This protein is an essential component of the dendritic cytoskeleton, especially in the adult brain, and its expression can be altered under experimental or pathological c...
É realizado estudo experimental comparativo entre dois métodos de proteçao cerebral na abordagem cirúrgica dos aneurismas do arco aórtico, avaliando a sua eficácia: hipotermia sistêmica profunda isolada (menor que 2O graus Celsius) com pinçamento arterial braquiocefálico e hipotermia sistêmica ...
