Ocotea duckei
, known as Louro
-
de
-
cheiro, belongs
to the Lauraceae family and presents
lignoid yangambine (YAN) as the main plant marker. This work aimed to develop and validate an
analytical method by high performance liquid chromatography for the quantification of YAN. Th...
Abstract A novel, simple and sensitive high-performance liquid chromatography with fluorescence detection method was developed and validated for the characterization of the preclinical pharmacokinetics of melatonin under pregnant conditions. Plasma samples (25 µL) were treated with 30 µL of ethanol abs...
We developed poly-ε-caprolactone (PCL)-based nanoparticles containing D-α-tocopherol polyethylene glycol-1000 succinate (TPGS) or Poloxamer 407 as stabilizers to efficiently encapsulate genistein (GN). Two formulations, referred to as PNTPGS and PNPol, were prepared using nanoprecipitation. They were c...
The Anh, Nguyen;
Van Chuyen, Nguyen;
Van Ba, Nguyen;
Thu Trang, Nguyen Thi;
Minh Phuong, Nguyen;
Van Kha, Tran;
Duc Minh, Tong;
Tuan Anh, Le;
Thi Truong, Hoang;
Van Manh, Phan;
Hoang Trung, Nguyen.
Introduction: Aflatoxins B1 are among the most common poisonous mycotoxins produced by certain fungi that harm animals and crops. Mycotoxins can cause a variety of adverse health effects and pose a serious health threat to humans. The Maximum Residue Limits of aflatoxin B1 in processed cereals and ingred...
Cardiovascular diseases involve hyperlipidemia, inflammation and oxidative stress. Although this relationship is well established, only biomarkers associated with hyperlipidemia and inflammation are currently in clinical practice for diagnosis and evaluation of patient treatment. Our hypothesis is that o...
Abstract Teicoplanin is a glycopeptide antibiotic commonly used to treat Gram-positive bacterial infections in the clinic. The aim of this study was to provide a therapeutic reference for the clinical application and dosage regimen adjustment of teicoplanin by identifying factors associated with its plas...
Abstract This study investigated the changes in the ingredients in Fallopia multiflora Thunb. Haraldson (FMT) root after processing it with different methods such as soaking, stewing, and steaming or combined methods. The total polyphenol, 2,3,5,4′-tetrahydroxystilben-2-O-β-D-glucoside (THSG), and ph...
Oliveira, Mariana Villas Bôas Vidal de;
Alves, Priscila Elias;
Teixeira, Jessica;
Monteiro, Mariana Sato de Souza de Bustamante;
Moreira, Tailane SantAnna;
Ricci Junior, Eduardo;
Santos, Elisabete Pereira dos;
Santos-Oliveira, Ralph;
Marins, Rita de Cássia Elias Estrela;
Freitas, Zaida Maria Faria de.
Abstract The objective of this paper was to develop and evaluate two semi-solid pharmaceutical forms containing 0.1% tacrolimus: cream (CRT01) and gel (GLT01). For the evaluation of physicochemical stability, at times 0, 30, 60 and 90 days, at 23°C and at 40°C, High Performance Liquid Chromatography co...
Abstract Brazilian green propolis has been widely used in food and pharmaceutical products due to its valuable source of phenolic compounds and versatile biological activities. The development and validation of analytical methods are extremely useful for the characterization and quality control of produc...
Abstract In the present study, the application of ultra-high performance liquid chromatography-tandem mass spectrometry allowed us to study of known-as well as hitherto unknown-trimetazidine (TMZ) metabolites in human urine and to propose their renal excretion profiles. Urine samples from a healthy volun...
