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Investigation of chromosomal alterations in patients with Alzheimer's disease in the state of Amazonas, Brazil

Nunes, Kledson Moraes; Benzaquem, Denise Corrêa; Carvalho, Natalia Dayane Moura; Vianez, Talísia Nascimento; Fernandes, Ernanda Raquel de Queirós Gonçalves de Sousa e; Fantin, Cleiton.
Arq. neuropsiquiatr; 77 (12), 2019
ABSTRACT Alzheimer's disease (AD) has as its main characteristic the deterioration of cerebral functions. Its etiology is still complex and undefined despite the progress made in understanding its neurological, infectious, biochemical, genetic and cytogenetic mechanisms. Considering this, the aim of this...
Cariotipo Anormal, Enfermedad de Alzheimer/genética, Enfermedad de Alzheimer/psicología, Aneuploidia, Brasil, Estudios de Casos y Controles, Aberraciones Cromosómicas, Cromosomas Humanos X/genética, Disfunción Cognitiva/psicología, Análisis Citogenético, Linfocitos
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Protocol for chromosome-specific probe construction using PRINS, micromanipulation and DOP-PCR techniques

PASSAMANI, PAULO Z; CARVALHO, CARLOS R; SOARES, FERNANDA A F.
An. acad. bras. ciênc; 90 (1), 2018
ABSTRACT Chromosome-specific probes have been widely used in molecular cytogenetics, being obtained with different methods. In this study, a reproducible protocol for construction of chromosome-specific probes is proposed which associates in situ amplification (PRINS), micromanipulation and degenerate ol...
Cromosomas Humanos X/genética, Análisis Citogenético/métodos, Cartilla de ADN/genética, Sondas de ADN/genética, Hibridación Fluorescente in Situ/métodos, Microdisección/métodos, Reacción en Cadena de la Polimerasa/métodos, Etiquetado in Situ Primed/métodos, Reproducibilidad de los Resultados
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