Introdução: Acidentes ofídicos são doenças negligenciadas e constituem uma parcela importante da morbidade de pessoas em idade produtiva que vivem em zonas rurais. A maior parte dos seus efeitos a curto prazo é amplamente conhecida, especialmente aqueles de natureza clínica; no entanto, ainda se o...
Introdução: Os acidentes ofídicos são eventos negligenciados em países
tropicais e em desenvolvimento, incluindo o Brasil. Serpentes do gênero
Crotalus são aquelas que produzem os quadros de maior letalidade no
país. Objetivos: Abordar os principais aspectos do acidente por Crotalus,
com ênfase ...
Abstract. Introduction: The thymus is active mainly during the neonatal and pre-adolescent periods. Objective: To test naïve thymocytes proliferation and monocytes stimulation. Materials and methods: We collected fresh thymus tissue from neonate mice after surgery. Suspension cells were coated onto Fico...
SUMMARY: The Viperidae venoms are composed of a mixture of constituents with enzymatic and non-enzymatic actions, which act on ultrastructural components of cells and tissues. Here, the number of mitochondria, mitochondrial area and the number of mitochondrial cristae from adrenal glands cortex treated w...
Abstract Background: Crotalus durissus is considered one of the most important species of venomous snakes in Brazil, due to the high mortality of its snakebites. The venom of Crotalus durissus contains four main toxins: crotoxin, convulxin, gyroxin and crotamine. Venoms can vary in their crotamine conte...
Silva-Júnior, Leandro Norberto da;
Abreu, Lara de Souza;
Rodrigues, Caroline Fabri Bittencourt;
Galizio, Nathália da Costa;
Aguiar, Weslei da Silva;
Serino-Silva, Caroline;
Santos, Valdomiro Souza dos;
Costa, Isabella Alves;
Oliveira, Luis Vicente Franco;
SantAnna, Sávio Stefanini;
Grego, Kathleen Fernandes;
Tanaka-Azevedo, Anita Mitico;
Rodrigues, Leandro Nascimento da Silva;
Morais-Zani, Karen de.
South American rattlesnakes are represented in Brazil by a single species, Crotalus durissus, which has public health importance due to the severity of its envenomation and to its wide geographical distribution. The species is subdivided into several subspecies, but the current classification is controve...
Carvalho, Letícia Helena de;
Teixeira, Leda Fabiélen;
Zaqueo, Kayena Delaix;
Bastos, Jéssica Felix;
Nery, Neriane Monteiro;
Setúbal, Sulamita Silva;
Pontes, Adriana Silva;
Butzke, Diana;
Cavalcante, Walter;
Gallacci, Marcia;
Fernandes, Carla Freire Celedônio;
Stabeli, Rodrigo Guerino;
Soares, Andreimar Martins;
Zuliani, Juliana Pavan.
Abstract INTRODUCTION: Crotalus envenomations cause serious complications and can be fatal without appropriate treatment. Venom isoforms present and inter/intraspecific variations in the venom composition can result in different symptoms presented by bites by snakes from the same species but from differ...
Fosfatasa Alcalina/sangre,
Fosfatasa Alcalina/efectos de los fármacos,
Creatina Quinasa/sangre,
Creatina Quinasa/efectos de los fármacos,
Creatinina/sangre,
Venenos de Crotálidos/toxicidad,
Crotalus/clasificación,
Edema/inducido químicamente,
Edema/patología,
Electroforesis en Gel de Poliacrilamida,
Riñón/efectos de los fármacos,
Riñón/patología,
L-Lactato Deshidrogenasa/sangre,
L-Lactato Deshidrogenasa/efectos de los fármacos,
Hígado/efectos de los fármacos,
Hígado/patología,
Ratones,
Modelos Animales,
Transaminasas/sangre,
Transaminasas/efectos de los fármacos,
Urea/sangre
The prevalent class of snake venom serine proteases (SVSP) in Viperidae venoms is the thrombin-like enzymes, which, similarly to human thrombin, convert fibrinogen into insoluble fibrin monomers. However, thrombin-like serine proteases differ from thrombin by being unable to activate factor XIII, thus le...
Resumo: No Brasil ocorrem anualmente cerca de 30.000 acidentes ofídicos, sendo os gêneros Bothrops e Crotalus responsáveis por 90% e 8% desses acidentes, respectivamente. Os envenenamentos botrópicos caracterizam-se por intensas reações inflamatórias locais, podendo evoluir para grandes perdas tec...
For the past 80 years, Crotoxin has become one of the most investigated isolated toxins from snake venoms, partially due to its major role as the main toxic component in the venom of the South American rattlesnake Crotalus durissus terrificus. However, in the past decades, progressive studies have led re...
