Background: Mammary gland tumors are the most prevalent neoplasm in intact female dogs, and they are good natural models to study comparative oncology. Most canine mammary malignancies, as in women, are commonly refractory to conventional therapies and demand continuous new therapeutic approaches. Crotal...
Introdução: Os acidentes ofídicos são eventos negligenciados em países
tropicais e em desenvolvimento, incluindo o Brasil. Serpentes do gênero
Crotalus são aquelas que produzem os quadros de maior letalidade no
país. Objetivos: Abordar os principais aspectos do acidente por Crotalus,
com ênfase ...
Snake venom phospholipases A2 (svPLA2) are biologically active toxins, capable of triggering and modulating a wide range of biological functions. Among the svPLA2s, crotoxin (CTX) has been in the spotlight of bioprospecting research due to its role in modulating immune response and hemostasis. In the pre...
For the past 80 years, Crotoxin has become one of the most investigated isolated toxins from snake venoms, partially due to its major role as the main toxic component in the venom of the South American rattlesnake Crotalus durissus terrificus. However, in the past decades, progressive studies have led re...
Background: Classically, Crotalus durissus terrificus (Cdt) venom can be described, according to chromatographic criteria, as a simple venom, composed of four major toxins, namely: gyroxin, crotamine, crotoxin and convulxin. Crotoxin is a non-covalent heterodimeric neurotoxin constituted of two subunits:...
A atividade da crotapotina (CA), a proteína não tóxica enzimática purifica e isolada a partir do complexo crotoxínico (CA + PLA2) foi estudada na resposta inflamatória aguda induzida por carragenina (1mg/pata), composto 48/80 (3 ug/pata) e serotonina 93 ug/pata) no edema de pata em ratos. Foram tam...
