BACKGROUND Hydroxycinnamic acids and some of their derivatives are molecules with interesting biological activities; for instance, hydroxylated hydroxycinnamic esters have proved to have antifungal properties, and thus the generation of these molecules is of industrial importance. In this study, the dire...
It is important to study the stability of plant extracts used as active ingredients in phytotherapic medicine, as degradation of the active principles directly affects the efficacy and safety of these products. Therefore, a stability study of the hydroalcoholic extract of the species: Mikania glomerata a...
Abstract Introduction: Parkinson's disease is the second most common neurodegenerative disease. Monoamine oxidase B inhibitors are used in the treatment of this disease concomitantly with levodopa or as monotherapy. Several substituted coumarins have shown activity as inhibitors of monoamine oxidase B. ...
Antiparkinsonianos/uso terapéutico,
Inhibidores de la Monoaminooxidasa/uso terapéutico,
Enfermedad de Parkinson Secundaria/tratamiento farmacológico,
Antiparkinsonianos/administración & dosificación,
Carbidopa/administración & dosificación,
Catalepsia/inducido químicamente,
Cumarinas,
Modelos Animales de Enfermedad,
Combinación de Medicamentos,
Evaluación Preclínica de Medicamentos,
Haloperidol,
Levodopa/administración & dosificación,
Locomoción/efectos de los fármacos,
Ratones Endogámicos ICR,
Inhibidores de la Monoaminooxidasa/administración & dosificación,
Enfermedad de Parkinson Secundaria/inducido químicamente,
Reserpina/administración & dosificación
An abnormality in the Lin28/let-7a axis is relevant to the progression of hepatitis B virus (HBV)-positive hepatocellular carcinoma (HCC), which could be a novel therapeutic target for this malignant tumor. The present study aimed to investigate the antiproliferative and anti-invasive effects of urolithi...
Análisis de Varianza,
Western Blotting,
Carcinoma Hepatocelular/tratamiento farmacológico,
Carcinoma Hepatocelular/genética,
Carcinoma Hepatocelular/virología,
Proliferación Celular/efectos de los fármacos,
Supervivencia Celular/efectos de los fármacos,
Cumarinas/farmacología,
Células Hep G2,
Neoplasias Hepáticas/tratamiento farmacológico,
Neoplasias Hepáticas/genética,
Neoplasias Hepáticas/virología,
MicroARNs/análisis,
MicroARNs/efectos de los fármacos,
Proteínas de Unión al ARN/análisis,
Proteínas de Unión al ARN/efectos de los fármacos,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Valores de Referencia,
Reproducibilidad de los Resultados,
Sincalida/análisis,
Factores de Tiempo,
Replicación Viral/efectos de los fármacos
Resumen La terapia anticoagulante es ampliamente utilizada en la práctica clínica, como profilaxis en pacientes con riesgo de presentar fenómenos tromboembólicos o como tratamiento en aquellos que han presentado algún evento trombótico. Cada vez es más frecuente enfrentarse a pacientes en tratamie...
Moléculas orgânicas fluorescentes são uma importante ferramenta para biologia celular. Compostos ideais para esta aplicação devem ter alto brilho (produto do coeficiente de atenuação molar e do rendimento quântico de fluorescência), ser fotoestáveis e internalizáveis, não comprometer a viabil...
ABSTRACT 6-Methylcoumarin (6MC) is a semisynthetic coumarin with important in vitro and in vivo anti-inflammatory activity. In order to continue the pre-clinical characterization of this molecule, in vitro intestinal permeability, plasma profile and tissue distribution after oral administration in rats w...
Justicia pectoralis Jacq., Acanthaceae, is a herb known popularly in Cuba as Tilo and used traditionally as sedative. The development in a solid pharmaceutical (Tablets 100 mg) using dry extract of Justicia pectolaris aqueous extract is of interest for the development of phytomedicines, which uses this a...
INTRODUCTION: Justicia pectoralis Jacq. (Acanthaceae) is medicinal plant species commonly used in Cuba for the treatment of nervous disorders because of its sedative effect. Coumarin is one of its main active phytochemicals present in the extracts obtained from this plant and used as analytic marker in q...
Three coumarins, 5-methoxypsoralene, xanthyletin, and (-)-marmesin, have been isolated from the ethanolic extract of the stem of the Amazonian plant Brosimum potabile. The structures were determined on the basis of NMR analyses and by comparison with spectroscopic data in the literature. The analysis of ...
