Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method
Braz. j. med. biol. res; 50 (11), 2017
This study aimed to investigate the absorption mechanism of three curcumin constituents in rat small intestines. Self-emulsification was used to solubilize the three curcumin constituents, and the rat in situ intestinal perfusion method was used to study factors on drug absorption, including drug mass co...
2,4-Dinitrofenol/farmacocinética, Transportadoras de Casetes de Unión a ATP/antagonistas & inhibidores, Adyuvantes Farmacéuticos/farmacologÃa, CromatografÃa LÃquida de Alta Presión/métodos, Curcumina/análogos & derivados, Curcumina/quÃmica, Curcumina/farmacocinética, Emulsiones, Inhibidores Enzimáticos/farmacocinética, Absorción Intestinal, Absorción Intestinal/efectos de los fármacos, Intestino Delgado/efectos de los fármacos, Intestino Delgado/metabolismo, ProteÃnas Asociadas a Resistencia a Múltiples Medicamentos/análisis, ProteÃnas Asociadas a Resistencia a Múltiples Medicamentos/antagonistas & inhibidores, Imagen de Perfusión/métodos, Probenecid/farmacologÃa, Ratas Sprague-Dawley, Valores de Referencia, Reproducibilidad de los Resultados, Factores de Tiempo, Desacopladores/farmacologÃa, Verapamilo/farmacologÃa