Background and Objectives: It is not clear whether the increase in nutrition students’ knowledge is associated with healthier eating behavior and fewer micronutrient deficiencies that can cause DNA damage. Deficiency in some vitamins can be a risk factor for increased homocysteine (Hcy) levels, a marke...
Abstract The present research was made to determine the micronuclei and cytotoxic capacity of the antidepressant venlafaxine in an in vivo acute and subchronic assays in mouse. In the first study, we administered once 5, 50, and 250 mg/kg of the drug, and included a negative and a daunorubicin treated gr...
A medula óssea é um compartimento complexo do corpo humano com funções cruciais para manutenção da fisiologia hematopoética, tendo componentes protagonistas como as células-tronco hematopoéticas (CTHs) que participam ativamente da produção dos fatores sanguíneos, e as células-tronco mesenqui...
Células Madre Mesenquimatosas/clasificación,
Citometría de Flujo/instrumentación,
d0185940,
Células Madre Hematopoyéticas/clasificación,
Daño del ADN/efectos de los fármacos,
Enfermedad/clasificación,
d0108270,
Neoplasias Hematológicas/prevención & control,
d0118780,
Técnicas de Cultivo de Célula/métodos,
Western Blotting/métodos
Abstract For many centuries human populations have been suffering and trying to fight with disease-bearing mosquitoes. Emerging and reemerging diseases such as Dengue, Zika, and Chikungunya affect billions of people around the world and recently has been appealing to control with chemical pesticides. Mal...
Abstract Nucleotide excision repair (NER) acts repairing damages in DNA, such as lesions caused by cisplatin. Xeroderma Pigmentosum complementation group C (XPC) protein is involved in recognition of global genome DNA damages during NER (GG-NER) and it has been studied in different organisms due to its i...
Abstract The present study was designed to investigate the effects of Gundelia tournefortii L. plant extract on different tissues in terms of DNA damage, biochemical and antioxidant parameter values in rats with high-calorie diets. With this aim, Wistar albino male rats were divided into 4 groups contain...
Borges, Daniela de Paula;
Santos, Rinna Maria Arruda Rodrigues dos;
Velloso, Elvira Rodrigues Pereira;
Ribeiro Junior, Howard Lopes;
Larripa, Irene Beatriz;
Camacho, Maria Fernanda;
González, Jacqueline;
Pratx, Leandro Daniel Burgos;
Magalhães, Sílvia Maria Meira;
Belli, Carolina Bárbara;
Pinheiro, Ronald Feitosa.
Abstract Nucleotide excision repair pathway (NER) is an essential mechanism for single-strand breaks (SSB) repair while xeroderma pigmentosum family (XPA to XPG) is the most important system to NER. Myelodysplastic syndrome (MDS) is a heterogeneous hematological cancer characterized by cytopenias and ris...
Las catequinas del té verde (Camellia sinensis) (CTV) presentan efectos benéficos para la salud asociados a su potencial antioxidante. Por otra parte, el estrés oxidante es una de las vías de inducción de daño genotóxico. De ahí que, en la presente revisión se realizó un análisis de los efecto...
Frâncica, L S;
Gonçalves, E V;
Santos, A A;
Vicente, Y S;
Silva, T S;
Gonzalez, R S;
Almeida, P M;
Feitoza, L L;
Bueno, P A A;
Souza, D C;
Peron, A P.
Flavoring additives are of great technological importance for the food industry. However, there is little information regarding the toxicological properties of these micro-ingredients, especially at the cellular level. The present study used meristematic root cells of Allium cepa L. to evaluate the toxic...
BACKGROUND: The assessment of sperm DNA integrity has been proposed as a complementary test to conventional mammalian semen analysis. In this sense, single-strand (SSB) and double-strand (DSB) DNA breaks, the two types of sperm DNA fragmentation (SDF), have been reported to have different aetiologies and...
