A medula óssea é um compartimento complexo do corpo humano com funções cruciais para manutenção da fisiologia hematopoética, tendo componentes protagonistas como as células-tronco hematopoéticas (CTHs) que participam ativamente da produção dos fatores sanguíneos, e as células-tronco mesenqui...
Células Madre Mesenquimatosas/clasificación,
Citometría de Flujo/instrumentación,
d0185940,
Células Madre Hematopoyéticas/clasificación,
Daño del ADN/efectos de los fármacos,
Enfermedad/clasificación,
d0108270,
Neoplasias Hematológicas/prevención & control,
d0118780,
Técnicas de Cultivo de Célula/métodos,
Western Blotting/métodos
Las catequinas del té verde (Camellia sinensis) (CTV) presentan efectos benéficos para la salud asociados a su potencial antioxidante. Por otra parte, el estrés oxidante es una de las vías de inducción de daño genotóxico. De ahí que, en la presente revisión se realizó un análisis de los efecto...
The melamine and cyanuric acid (CA) complex has been suggested to cause the toxic effects observed in melamine-contaminated food or milk. However, the cytotoxic and genotoxic effects of co-exposure to melamine and CA are not fully clear. Therefore, the cytotoxic effects of melamine and CA were first exam...
Gomes, L C;
Chippari-Gomes, A R;
Miranda, T O;
Pereira, T M;
Merçon, J;
Davel, V C;
Barbosa, B V;
Pereira, A C H;
Frossard, A;
Ramos, J P L.
Abstract The Doce River basin has suffered the largest environmental accident ever occurred in Brazil with the influx of tailings from Fundão and Santarém, belonging to Samarco mining company, due to the disaster in Mariana. A spill between 50 and 60 million m3 of tailings was estimated by the company...
Brasil,
Cíclidos/genética,
Cíclidos/fisiología,
Daño del ADN/efectos de los fármacos,
Desastres,
Monitoreo del Ambiente/métodos,
Agua Dulce/química,
Metales Pesados/análisis,
Metales Pesados/clasificación,
Metales Pesados/toxicidad,
Minería,
Ríos/química,
Contaminantes Químicos del Agua/análisis,
Contaminantes Químicos del Agua/clasificación,
Contaminantes Químicos del Agua/toxicidad
ABSTRACT BACKGROUND: Gastric cancer is the second leading cause of cancer-related death globally. Unfortunately, the survival rate of the gastric cancer patients who underwent chemotherapy following surgery has been less than a half. Besides, chemotherapy has many side effects. Current evidence suggest...
ABSTRACT Objective To evaluate the induction of DNA damage in peripheral blood mononuclear cells of patients with sickle cell disease, SS and SC genotypes, treated with hydroxyurea. Methods The study subjects were divided into two groups: one group of 22 patients with sickle cell disease, SS and SC g...
Anemia de Células Falciformes/tratamiento farmacológico,
Anemia de Células Falciformes/genética,
Citocinesis,
Daño del ADN/efectos de los fármacos,
Daño del ADN/genética,
Hidroxiurea/efectos adversos,
Hidroxiurea/farmacología,
Hidroxiurea/uso terapéutico,
Pruebas de Micronúcleos,
Persona de Mediana Edad,
Pruebas de Mutagenicidad,
Mutación/efectos de los fármacos,
Inhibidores de la Síntesis del Ácido Nucleico/efectos adversos,
Inhibidores de la Síntesis del Ácido Nucleico/farmacología,
Inhibidores de la Síntesis del Ácido Nucleico/uso terapéutico
This study was aimed to search the effect of wheatgrass on the Total Antioxidan (TAS)-Oxidan Status (TOS) and DNA damage in rat with diabetes. The rats used in the study were randomly divided into 4 groups that each of has 10 rats: Control group; 1 ml single dose phosphate-citrate buffer injected i.p (pH...
Triticum/química,
Extractos Vegetales/administración & dosificación,
Diabetes Mellitus Experimental/tratamiento farmacológico,
Antioxidantes/análisis,
Estrés Oxidativo/efectos de los fármacos,
Páncreas/efectos de los fármacos,
Ratas Wistar,
Daño del ADN/efectos de los fármacos,
Oxidantes/sangre,
Células Secretoras de Insulina/efectos de los fármacos,
Extractos Vegetales/farmacología,
Glucemia/efectos de los fármacos
Abstract Handroanthus impetiginosus has long been used in traditional medicine and various studies have determined the presence of bioactive chemical compounds and potential phytotherapeutics. In this study, the genotoxicity of the lyophilized tincture of H. impetiginosus bark (THI) was evaluated in mous...
Environmental exposure to genotoxic agents represents a major health concern for modern society. DNA damage could lead to mutations, which accumulative effect is closely related to degenerative and lethal diseases, such as cancer. Because of their structural and chemical diversity natural products play a...
The tumor suppressive role of oridonin, an active compound extracted from Rabdosia rubescens, has been proven in several gastric cancer (GC) cell lines. The present study aimed to evaluate the effect of oridonin on another GC cell line, SNU-216, and explore the potential mechanisms. The viable cell numbe...
Antineoplásicos/farmacología,
Apoptosis/efectos de los fármacos,
Western Blotting,
Carcinoma/tratamiento farmacológico,
Carcinoma/metabolismo,
Carcinoma/patología,
Caspasa 3/análisis,
Caspasa 9/análisis,
Línea Celular Tumoral,
Proliferación Celular/efectos de los fármacos,
Supervivencia Celular/efectos de los fármacos,
Daño del ADN/efectos de los fármacos,
Diterpenos de Tipo Kaurano/farmacología,
Citometría de Flujo,
Células HEK293,
Reproducibilidad de los Resultados,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Neoplasias Gástricas/tratamiento farmacológico,
Neoplasias Gástricas/metabolismo,
Neoplasias Gástricas/patología,
Proteína p53 Supresora de Tumor/análisis
