Abstract Intestinal ischemia/reperfusion (I/R) causes barrier impairment and bacterial influx. This study explored the protective effects of anisodamine hydrobromide (AH) on intestinal I/R injury caused by cardiopulmonary resuscitation (CPR) after cardiac arrest (CA). After successful CPR, minipigs were ...
Isquemia/patología,
Reanimación Cardiopulmonar/clasificación,
ddcs0251220,
d0658400,
Heridas y Lesiones/complicaciones,
Fibrilación Ventricular/tratamiento farmacológico,
d0064390,
d0087220,
Porcinos Enanos/clasificación,
Reperfusión/instrumentación,
Porcinos/clasificación,
d0189880,
Daño por Reperfusión/complicaciones
Honey is a natural antioxidant that its protective effects have been proven against ischemia-reperfusion (IR) injury. The aim of this study was to evaluate the ameliorative effect of Persian Honey, Apis mellifera meda skorikov, on gastrocnemius muscle IR injury. Eighty adult male Sprague-Dawley rats weig...
ABSTRACT Background: Tacrolimus and mycophenolate mofetil are immunosuppressive agents widely used on the postoperative period of the transplants. Aim: To evaluate the influence of the association of them on the abdominal wall healing in rats. Methods: Thirty-six Wistar rats were randomly assigned ...
Pared Abdominal/cirugía,
Inmunosupresores/farmacología,
Isquemia,
Riñón/irrigación sanguínea,
Ácido Micofenólico/administración & dosificación,
Ácido Micofenólico/farmacología,
Ratas Wistar,
Reperfusión,
Daño por Reperfusión/complicaciones,
Tacrolimus/administración & dosificación,
Tacrolimus/farmacología
Abstract Purpose Composite flaps used in reconstructive surgery may intra- and postoperatively suffer from hypoperfusion and/or ischemia-reperfusion influencing wound healing. We aimed to follow-up the effect of ischemia on adipocutaneous flaps' wound healing and microcirculation. Methods In anesthet...
Biopsia,
Temperatura Corporal,
Procedimientos Quirúrgicos Dermatologicos/efectos adversos,
Modelos Animales de Enfermedad,
Flujometría por Láser-Doppler,
Microcirculación/fisiología,
Colgajo Miocutáneo/irrigación sanguínea,
Colgajo Miocutáneo/patología,
Periodo Posoperatorio,
Valores de Referencia,
Daño por Reperfusión/complicaciones,
Daño por Reperfusión/patología,
Reproducibilidad de los Resultados,
Piel/irrigación sanguínea,
Piel/patología,
Factores de Tiempo,
Resultado del Tratamiento,
Cicatrización de Heridas/fisiología
Cury, Maria Fernanda Ribeiro;
Olivares, Estéfany Queiroz;
Garcias, Renata Correia;
Toledo, Giovana Queda;
Anselmo, Natassia Alberici;
Paskakulis, Leticia Colombo;
Botelho, Fernanda Fortuci Resende;
Carvalho, Natiele Zanardo;
Silva, Analice Andreoli da;
Agren, Camila;
Carlos, Carla Patrícia.
ABSTRACT Introduction: Ischemia and reperfusion (IR) is a process inherent to the procedures involved in the transplantation of organs that causes inflammation, cell death and cell injury, and may lead to rejection of the graft. It is possible that the anti-inflammatory properties of the Brazil nuts (BN...
Abstract Purpose: To investigate the effect of metyrosine against I/R induced gastric damage in rats. Methods: Eighteen albino Wistar male rats were divided into groups; gastric I/R (GIR), 50 mg/kg metyrosine+gastric I/R (MGIR), and sham (SG) groups. 50 mg/kg metyrosine was given to the MGIR group, a...
Anselmo, Natassia Alberici;
Paskakulis, Leticia Colombo;
Garcias, Renata Correia;
Botelho, Fernanda Fortuci Resende;
Toledo, Giovana Queda;
Cury, Maria Fernanda Ribeiro;
Carvalho, Natiele Zanardo;
Mendes, Glória Elisa Florido;
Iembo, Tatiane;
Bizotto, Thaís Santana Gastardelo;
Cury, Patricia Maluf;
Chies, Agnaldo Bruno;
Carlos, Carla Patrícia.
ABSTRACT Introduction: Ischemia-reperfusion (IR) injury results from inflammation and oxidative stress, among other factors. Because of its anti-inflammatory and antioxidant properties, the Brazil nut (BN) might attenuate IR renal injury. Objective: The aim of the present study was to investigate wheth...
Abstract Purpose: To analyze the effects of allopurinol and of post-conditioning on lung injuries induced by lower-limb ischemia and reperfusion. Methods: Thirty rats were used. They were divided in 5 groups: (1) group A: abdominal aortic dissection only, (2) group B: ischemia and reperfusion, (3) gro...
ABSTRACT BACKGROUND Ischemia/reperfusion causes organ damage but it is mandatory in hepatic transplantation, trauma and other complex liver surgeries, when Pringle maneuver is applied to minimize bleeding during these procedures. It is well known that liver ischemia/reperfusion leads to microcirculator...
Alanina Transaminasa/sangre,
Aspartato Aminotransferasas/sangre,
Modelos Animales de Enfermedad,
Hipotermia Inducida,
Fallo Hepático Agudo/etiología,
Fallo Hepático Agudo/patología,
Fallo Hepático Agudo/prevención & control,
Necrosis,
Ratas Wistar,
Daño por Reperfusión/complicaciones,
Daño por Reperfusión/patología,
Índice de Severidad de la Enfermedad
Abstract Purpose: Ischemia-reperfusion injury is one of the consequences of tourniquet application for extremity surgery. The aim of the study was to establish the effect of dexmedetomidine on the acute lung injury following lower extremity experimental ischemia-reperfusion model in rats. Methods: Twen...
Lesión Pulmonar Aguda/prevención & control,
Agonistas de Receptores Adrenérgicos alfa 2/administración & dosificación,
Agonistas de Receptores Adrenérgicos alfa 2/farmacología,
Dexmedetomidina/administración & dosificación,
Dexmedetomidina/farmacología,
Modelos Animales de Enfermedad,
Relación Dosis-Respuesta a Droga,
Interleucina-6/sangre,
Extremidad Inferior/irrigación sanguínea,
Ratas Wistar,
Daño por Reperfusión/complicaciones,
Daño por Reperfusión/tratamiento farmacológico,
Torniquetes/efectos adversos,
Factor de Necrosis Tumoral alfa/sangre
