LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

The effects of local ischemic preconditioning and topical hypothermia in renal ischemia/reperfusion injury in rats

Ribeiro, Guilherme Behrend; Santos, Emanuel Burck dos; Bona, Silvia Regina; Schaefer, Pedro Guilherme; Garcez, Tuane Alves; Rabolini, Eduardo Brasil; Smaniotto, Guilherme Pereira; Marroni, Norma Possa; Corso, Carlos Otávio.

Acta cir. bras; 32 (10), 2017

Abstract Purpose: Topical hypothermia and local ischemic preconditioning have been shown to reduce renal ischemia-reperfusion (I/R) injury individually. We examined whether combination of both strategies lessens renal I/R injury. Methods: Post right nephrectomy, 40 male Wistar rats were randomly assi...

Modelos Animales de Enfermedad, Hipotermia Inducida/métodos, Precondicionamiento Isquémico/métodos, Riñón/irrigación sanguínea, Riñón/química, Riñón/patología, Peroxidación de Lípido, Nefrectomía, Distribución Aleatoria, Ratas Wistar, Daño por Reperfusión/sangre, Daño por Reperfusión/patología, Daño por Reperfusión/prevención & control

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The renoprotective effect of oral Tadalafil pretreatment on ischemia/reperfusion injury in rats

Abstract Purpose: To evaluate the effect of tadalafil in renal ischemia/reperfusion (I/R) injury in rats Methods: Group I/R saline rats (n=6) were subjected to 45 minutes of left renal ischemia and treated with saline; the I/R tadalafil rats (n=6) received oral 10mg/kg tadalafil microemulsion one hou...