Taha, Medhat;
Ibrahim, Mohie Mahmoud;
Elazab, Sara T;
Badawy, Alaa. M;
Abdelsalam, Ramy A;
Saati, Abdullah A;
Qusty, Naeem F;
Babateen, Omar;
Abdelbagi, Omer;
Hendawy, M.
SUMMARY: One of the reasons for acute kidney damage is renal ischemia. Nevertheless, there are limited protective and therapeutic approaches for this problem. Diacerein is an anti-inflammatory drug characterized by numerous biological activities. We aimed to determine the ameliorative impact of diacerein...
Antraquinonas/administración & dosificación,
Antiinflamatorios/administración & dosificación,
Daño por Reperfusión/tratamiento farmacológico,
Antraquinonas/inmunología,
Células Dendríticas/efectos de los fármacos,
Apoptosis/efectos de los fármacos,
Enfermedades Renales/tratamiento farmacológico,
Daño por Reperfusión/inmunología,
Enfermedades Renales/inmunología,
Inyecciones Intraperitoneales,
FN-kappa B/metabolismo,
Receptor Toll-Like 4/metabolismo,
Transducción de Señal,
Estrés Oxidativo,
Inflamación,
Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo,
Interleucina-1beta/metabolismo,
Citometría de Flujo,
d0201690,
d0200110
Celepli, Salih;
Çolak, Bayram;
Celepli, Pınar;
Bigat, İrem;
Batur, Hatice Gül;
Soysal, Furkan;
Karakurt, Serdar;
Hücümenoğlu, Sema;
Kısmet, Kemal;
Şahin, Mustafa.
SUMMARY OBJECTIVE: The aim of this study was to evaluate the hepatoprotective effect and mechanism of action of artichoke leaf extract in hepatic ischemia/reperfusion injury. METHODS: Rats were divided into three groups such as sham, control, and artichoke leaf extract groups. Antioxidant enzyme acti...
Introduction:
Myocardial ischemia-reperfusion (I/R) injury is one of the mechanisms contributing to the high mortality rate of acute myocardial infarction.
Purpose:
This study intended to study the role of naringin in cardiac I/R injury.
Methods:
AC16 cells (human cardiomyocyte cell line) were subjecte...
SUMMARY: Ischemia-reperfusion (I/R) of the small intestine causes serious abdominal pathologies including tissue dysfunction and organ failure. L-carnitine (L-C), a powerful antioxidant, may help lessen the severity of these pathological effects since it plays a key role in energy metabolism. In this wor...
Resumo Fundamento: O núcleo do trato solitário (NTS) é uma área do cérebro que desempenha um papel fundamental na regulação renal e cardiovascular através dos impulsos dos barorreceptores. Objetivos: O objetivo deste estudo foi avaliar o efeito da Naringina (NAR) e trimetazidina (TMZ), isoladam...
SUMMARY: Renal ischemia-reperfusion injury (IRI)is an unavoidable consequence in renal transplantation and multiple clinical settings. A debate has been raised about the particular role of hypoxia-inducible factor (HF-1α) in the renal injury pathogenesis and the renal cortex ultrastructural alterati...
SUMMARY: We aimed to investigate the possible protective effects of Potentilla fulgens on kidney tissue with ischemia- reperfusion using immunohistochemical methods. Wistar rats were grouped as sham, ischemia, ischemia-reperfusion (I/R) and I/R treated with Potentilla fulgens. Renal vessels of the left r...
Potentilla/química,
Extractos Vegetales/administración & dosificación,
Extractos Vegetales/farmacología,
Modelos Animales de Enfermedad,
Daño por Reperfusión/tratamiento farmacológico,
Enfermedades Renales/tratamiento farmacológico,
Proteína ADAMTS5/metabolismo,
Caspasa 3/metabolismo,
Ratas Wistar,
Inmunohistoquímica,
Sustancias Protectoras
ABSTRACT Purpose: The protective effect of silibinin on kidney and lung parenchyma during hepatic ischemia/reperfusion injury (IRI) is explored. Methods: Sixty-three Wistar rats were separated into three groups: sham; control (45 min IRI); and silibinin (200 μL silibinin administration after 45 mi...
Daño por Reperfusión/tratamiento farmacológico,
Ratas Wistar,
Metaloproteinasa 9 de la Matriz,
Metaloproteinasa 3 de la Matriz,
Metaloproteinasa 2 de la Matriz,
Pulmón,
Hepatopatías,
Riñón,
Isquemia,
Inhibidor Tisular de Metaloproteinasa-2,
Silibina,
Daño por Reperfusión/prevención & control
ABSTRACT Purpose: To investigate the protective effect of parecoxib against lung ischemia-reperfusion injury (LIRI) in rats and the mechanism. Methods: Thirty rats were divided into sham-operated, LIRI and LIRI+parecoxib groups. LIRI model (ischemia for 60 min, followed by reperfusion for 120 min) was ...
ABSTRACT Purpose: To evaluate the protective effect of dexmedetomidine on gastric injury induced by ischemia reperfusion (I/R) in rats. Methods: A total of 18 male albino Wistar rats were divided groups as: gastric ischemia reperfusion (GIR), gastric ischemia reperfusion and 50 μg/kg dexmedetomidi...
