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Nonadherence to treatment recommendations is a factor contributing to the clinical failure of daptomycin: Cohort study in Brazil

Martins, Tathiana Silva de Souza; Figueras, Albert; Souza, Luana dos Reis de; Santos, Keila Cristina Oliveira dos; Oliveira, Elaine Machado de; Secoli, Silvia Regina.
Braz. J. Pharm. Sci. (Online); 56 (), 2020
To evaluate the clinical outcomes of daptomycin therapy and adherence to treatment recommendations, a retrospective cohort study was conducted with patients that received daptomycin during the period of the study. The adherence and nonadherence to clinical guidelines were assessed through organism identi...
Daptomicina/análisis, Estudios de Cohortes, Insuficiencia del Tratamiento, Antibacterianos/efectos adversos, Enfermedades Transmisibles/complicaciones, Dosificación/efectos adversos, Organización Mundial de la Salud, Pacientes/clasificación, Infecciones por Bacterias Grampositivas/clasificación, Vigilancia de Productos Comercializados
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A fully validated microbiological assay for daptomycin injection and comparison to HPLC method

Christ, Ana Paula; Machado, Mariana Souto; Ribas, Karla Giacomelli; Schwarzbold, Alexandre Vargas; Silva, Cristiane de Bona da; Adams, Andréa Inês Horn.
Braz. j. pharm. sci; 51 (4), 2015
abstract Daptomycin (DPT) was the first lipopeptide antibiotic available for commercialization. It is active against gram-positive bacteria, including resistant strains. This work aimed to develop and validate a turbidimetric microbiologic assay to determine daptomycin in an injectable form. A 3x3 design...
Cromatografía Líquida de Alta Presión/métodos, 25783/análisis, Control de Calidad, Daptomicina/análisis
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A green approach for the quantification of daptomycin in pharmaceutical formulation by UV spectrophotometry

Tótoli, Eliane Gandolpho; Salgado, Hérida Regina Nunes.
Braz. j. pharm. sci; 51 (4), 2015
abstract Daptomycin is the first approved drug from a new class of antimicrobials, the cyclic lipopeptides, and is a very important antimicrobial agent in current clinical practice. Currently, there are no "green" analytical methods described in the literature to analyze the typical pharmaceutical dosage...
Daptomicina/análisis, Química Farmacéutica/clasificación, Espectrofotometría Ultravioleta/22074, Antiinfecciosos/análisis, Control de Calidad
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