LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Nuclear factor erythroid-2 related factor 2 inhibits human disc nucleus pulpous cells apoptosis induced by excessive hydrogen peroxide

SUMMARY OBJECTIVE Nuclear factor erythroid-2 related factor 2 (Nrf2)/ antioxidant response element (ARE) is a novel defensive pathway involved in the oxidative and chemical stress of cells. The aim of the study was to explore the role of Nrf2 on the apoptosis of human disc nucleus pulpous cells induced...

Ginsenoside Rd inhibits IL-1β-induced inflammation and degradation of intervertebral disc chondrocytes by increasing IL1RAP ubiquitination

Zhang, Wei-Jia; Liu, Ying; Wei, Jie-Shu; Wu, Ya-Li.

Braz. j. med. biol. res; 52 (9), 2019

Many compounds of ginsenosides show anti-inflammatory properties. However, their anti-inflammatory effects in intervertebral chondrocytes in the presence of inflammatory factors have never been shown. Increased levels of pro-inflammatory cytokines are generally associated with the degradation and death o...

Agrecanos/metabolismo, Supervivencia Celular/efectos de los fármacos, Condrocitos/citología, Condrocitos/efectos de los fármacos, Condrocitos/metabolismo, Ciclooxigenasa 2/metabolismo, Dinoprostona/metabolismo, Ginsenósidos/metabolismo, Ginsenósidos/farmacología, Inflamación/metabolismo, Proteína Accesoria del Receptor de Interleucina-1/metabolismo, Interleucina-1beta/efectos de los fármacos, Interleucina-1beta/metabolismo, Degeneración del Disco Intervertebral/metabolismo, Dolor de la Región Lumbar/metabolismo, Óxido Nítrico Sintasa/metabolismo, Núcleo Pulposo/citología, Núcleo Pulposo/efectos de los fármacos, Núcleo Pulposo/metabolismo, Factor de Necrosis Tumoral alfa/metabolismo, Ubiquitinación

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