LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

A study on the antioxidant activity of rosmarinic acid against carbon tetrachloride-induced liver toxicity in adult male albino rats

Badawi, Marwa Sayed.

Int. j. morphol; 40 (1), 2022

SUMMARY: Carbon tetrachloride (CCl4) is a manufactured chemical and does not occur naturally in the environment. CCl4 is a clear liquid that evaporates very easily. It has a sweet odor. CCl4 is toxic to the mammalian liver and is hepatocarcinogenic in both rats and mice. Rosemary (Rosmarinus Officinalis)...

Enfermedad Hepática Inducida por Sustancias y Drogas/tratamiento farmacológico, Cinamatos/administración & dosificación, Depsidos/administración & dosificación, Antioxidantes/administración & dosificación, Tetracloruro de Carbono/toxicidad, Inmunohistoquímica, Estrés Oxidativo/efectos de los fármacos, Microscopía Electrónica de Transmisión, Cinamatos/farmacología, Depsidos/farmacología, Antioxidantes/farmacología, Malondialdehído/análisis, Glutatión Peroxidasa/análisis, Superóxido Dismutasa/análisis

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Anti-fibrotic effects of rosmarinic acid on Tenon's capsule fibroblasts stimulated with TGF-ß: therapeutic potential in ocular surgery

Módulo, Carolina Maria; Ferreira, Larissa Domenegueti; Silva, Lilian Eslaine Costa Mendes da; Frade, Marco Andrey Cipriani; Reinach, Peter Sol; Rocha, Eduardo Melani; Paula, Jayter Silva.

Arq. bras. oftalmol; 83 (4), 2020

ABSTRACT Purpose: Collagen deposition and myofibroblast differentiation are critical factors related to excessive scarring in ocular surgeries. This study evaluated the anti-fibrotic activity of rosmarinic acid on rabbit Tenon's capsule fibroblasts stimulated with transforming growth factor- β2. M...

Cápsula de Tenon, Células Cultivadas, Cinamatos, Depsidos, Fibroblastos, Glaucoma, Conejos

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The effect of rosmarinic acid on deformities occurring in brain tissue by craniectomy method. Histopathological evaluation of IBA-1 and GFAP expressions

Özevren, Hüseyin; Deveci, Engin; Tuncer, Mehmet Cudi.

Acta cir. bras; 35 (4), 2020

Abstract Purpose To investigate the role of Rosmarinic acid (RA) in the prevention of traumatic brain injury and the immunohistochemical analysis of IBA-1 and GFAP expressions. Methods Healthy male rats were randomly divided into 3 groups consisting of 10 rats. Groups were as follows; control group, tr...

Astrocitos/efectos de los fármacos, Lesiones Traumáticas del Encéfalo/patología, Lesiones Traumáticas del Encéfalo/prevención & control, Lesiones Traumáticas del Encéfalo/cirugía, Proteínas de Unión al Calcio/análisis, Cinamatos/farmacología, Craneotomía/métodos, Depsidos/farmacología, Proteína Ácida Fibrilar de la Glía/análisis, Glutatión Peroxidasa/análisis, Inmunohistoquímica, Malondialdehído/análisis, Proteínas de Microfilamentos/análisis, Fármacos Neuroprotectores/farmacología, Distribución Aleatoria, Ratas Sprague-Dawley, Valores de Referencia, Reproducibilidad de los Resultados

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