LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Evaluation of the profile of inflammatory cytokines, through immunohistochemistry, in the skin of patients with allergic contact dermatitis to nickel in the acute and chronic phases

Silvestre, Marilene Chaves; Reis, Vitor Manoel Silva dos.

An. bras. dermatol; 93 (6), 2018

Abstract: Background: Allergic contact dermatitis to ion nickel (Ni+2) is an inflammatory dermatosis, common in industrialized countries. It involves the activation of nickel-specific T-cells, followed by proliferation and induction of a mixed profile of both proinflammatory and regulatory cytokines, su...

Enfermedad Aguda, Biopsia, Enfermedad Crónica, Citocinas/análisis, Citocinas/inmunología, Dermatitis Alérgica por Contacto/etiología, Dermatitis Alérgica por Contacto/inmunología, Dermatitis Alérgica por Contacto/patología, Inmunohistoquímica, Interferón gamma/análisis, Interferón gamma/inmunología, Interleucinas/análisis, Interleucinas/inmunología, Níquel/efectos adversos, Níquel/inmunología, Estudios Prospectivos, Factor de Necrosis Tumoral alfa/análisis, Factor de Necrosis Tumoral alfa/inmunología

Fulltext

Innate immunity and effector and regulatory mechanisms involved in allergic contact dermatitis

Abstract: Skin's innate immunity is the initial activator of immune response mechanisms, influencing the development of adaptive immunity. Some contact allergens are detected by Toll-like receptors (TLRs) and inflammasome NLR3. Keratinocytes participate in innate immunity and, in addition to functioning ...