ABSTRACT Diabetes is a life-threatening disease, and currently available synthetic medicines for treating diabetes are associated with various side effects. Therefore, there is an unmet need to develop herbal remedies against diabetes as an alternative to synthetic medicines. Although local healers use t...
Abstract In the present study, free interstitial levels reached by metformin in the liver were investigated in control and diabetic rats by microdialysis. Firstly, a bioanalytical method using an HPLC-UV system to determine the drug concentration in microdialysis samples was validated. The blood glucose ...
Abstract Insulin receptors have distributed in all brain regions, including the nucleus Accumbens (NAc), and where is implicated in the reward properties of drugs. It is well known that insulin signaling can regulate dopamine release. Therefore, in the present study, we tried to examine the effect of ins...
Introducción: Debido a sus propiedades químicas, la estreptozotocina es uno de los agentes diabetogénicos más utilizados para generar modelos biológicos de diabetes, por lo que es necesario estudiar cuáles son sus efectos en el organismo del animal de laboratorio. Objetivo: Evaluar, en un periodo d...
Abstract Purpose To explore the role of all-trans retinoic acid (ATRA) in renal ischemia/reperfusion injury of diabetic rats. Methods Sixty adult male rats were randomly divided into 6 groups, including sham group (S group), ischemia-reperfusion group (I/R group), ischemia-reperfusion+ATRA group (A g...
Diabetes Mellitus Experimental/inducido químicamente,
Modelos Animales de Enfermedad,
Evaluación Preclínica de Medicamentos,
Riñón/efectos de los fármacos,
Riñón/patología,
Factor 2 Relacionado con NF-E2/farmacología,
Factor 2 Relacionado con NF-E2/uso terapéutico,
Daño por Reperfusión/patología,
Daño por Reperfusión/prevención & control,
Estreptozocina,
Tretinoina/farmacología,
Tretinoina/uso terapéutico
Abstract Introduction: It is hypothesized that increased macrophage migration inhibitory factor (MIF) expression may contribute to diabetic nephropathy (DN) pathogenesis. The aim of the present study was to investigate the renal effects of MIF inhibition in a diabetic experimental model. Methods: Eight...
Albuminuria/tratamiento farmacológico,
Glucemia,
Creatinina/sangre,
Creatinina/orina,
Diabetes Mellitus Experimental/sangre,
Diabetes Mellitus Experimental/inducido químicamente,
Diabetes Mellitus Experimental/patología,
Diabetes Mellitus Experimental/orina,
Nefropatías Diabéticas/sangre,
Nefropatías Diabéticas/terapia,
Nefropatías Diabéticas/patología,
Nefropatías Diabéticas/orina,
Modelos Animales de Enfermedad,
Glicosaminoglicanos/orina,
Oxidorreductasas Intramoleculares/antagonistas & inhibidores,
Riñón/patología,
Activación de Macrófagos,
Factores Inhibidores de la Migración de Macrófagos/antagonistas & inhibidores,
Sustancias Protectoras/farmacología,
Sustancias Protectoras/uso terapéutico,
Ratas Wistar,
Estreptozocina/farmacología
ABSTRACT Objective: To investigate the anti-hyperglycemic effects of Plathymenia reticulata hydroalcoholic extract and related changes in body weight, lipid profile and the pancreas. Methods: Diabetes was induced in 75 adult male Wistar rats via oral gavage of 65mg/Kg of streptozotocin. Rats were alloc...
Glucemia/análisis,
Peso Corporal/efectos de los fármacos,
Colesterol,
Diabetes Mellitus Experimental/inducido químicamente,
Diabetes Mellitus Experimental/tratamiento farmacológico,
Modelos Animales de Enfermedad,
Fabaceae,
Hiperplasia/patología,
Hipoglucemiantes/farmacología,
Fitoterapia,
Extractos Vegetales/farmacología,
Hojas de la Planta,
Ratas Wistar,
Estreptozocina
Kuga, Gabriel Keine;
Gaspar, Rafael Calais;
Muñoz, Vitor Rosetto;
Nakandakari, Susana Castelo Branco Ramos;
Breda, Leonardo;
Sandoval, Bruna Marina;
Caetano, Flávio Henrique;
Leme, José Alexandre Curiacos de Almeida;
Pauli, José Rodrigo;
Gomes, Ricardo José.
ABSTRACT Objective To investigate the effects of physical training on metabolic and morphological parameters of diabetic rats. Methods Wistar rats were randomized into four groups: sedentary control, trained control, sedentary diabetic and trained diabetic. Diabetes mellitus was induced by Alloxan (3...
Glucemia/metabolismo,
Peso Corporal,
Diabetes Mellitus Experimental/inducido químicamente,
Diabetes Mellitus Experimental/metabolismo,
Prueba de Esfuerzo,
Insulina,
Factor I del Crecimiento Similar a la Insulina/metabolismo,
Hígado/anatomía & histología,
Hígado/metabolismo,
Hígado/ultraestructura,
Glucógeno Hepático/metabolismo,
Mitocondrias Hepáticas/ultraestructura,
Condicionamiento Físico Animal/fisiología,
Distribución Aleatoria,
Ratas Wistar,
Natación/fisiología
Abstract Activity of hepatic metabolic enzymes of glucuronidation and sulfation of 4-nitrophenol (PNP) and biliary excretion of its glucuronide (PNP-G) and sulfate (PNP-S) conjugates have been investigated in control and streptozotocin (STZ)-induced diabetic rats. 500 μM PNP solution was luminally perf...
Abstract Background: Diabetes mellitus is a severe chronic disease leading to systemic complications, including cardiovascular dysfunction. Previous cell therapy studies have obtained promising results with the use bone marrow mesenchymal stromal cells derived from healthy animals (MSCc) in diabetes ani...
Glucemia/metabolismo,
Diferenciación Celular,
Tratamiento Basado en Trasplante de Células y Tejidos,
Células Cultivadas,
Diabetes Mellitus Experimental/inducido químicamente,
Cardiopatías/etiología,
Cardiopatías/terapia,
Trasplante de Células Madre Mesenquimatosas,
Células Madre Mesenquimatosas/citología,
Células Madre Mesenquimatosas/metabolismo,
Ratas Wistar
