LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

The relationship between of ACE I/D and the MTHFR C677T polymorphisms in the pathophysiology of type 2 diabetes mellitus in a population of Brazilian obese patients

Pirozzi, Flavio Fontes; Belini Junior, Edis; Okumura, Jessika Viviani; Salvarani, Mariana; Bonini-Domingos, Claudia Regina; Ruiz, Milton Artur.

Arch. endocrinol. metab. (Online); 62 (1), 2018

ABSTRACT Objectives This study aimed to evaluate the frequencies of the angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) and methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphisms in obese patients with and without type 2 diabetes mellitus (T2DM). Subjects and methods The...

Brasil, Estudios de Casos y Controles, Diabetes Mellitus Tipo 2/complicaciones, Diabetes Mellitus Tipo 2/enzimología, Diabetes Mellitus Tipo 2/genética, Eliminación de Gen, Predisposición Genética a la Enfermedad, Genotipo, Metilenotetrahidrofolato Reductasa (NADPH2)/genética, Mutagénesis Insercional, Obesidad/complicaciones, Obesidad/enzimología, Peptidil-Dipeptidasa A/genética, Reacción en Cadena de la Polimerasa, Polimorfismo Genético/genética, Factores de Riesgo

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Xanthine oxidase activity in patients with age-related cataract associated with hypertension

Reactive oxygen species and lipid peroxidation are important factors that contribute to the development of age-related cataract. The study included 130 patients with age-related cataract, 69 of whom were diagnosed with hypertension (HT), 20 with hypertension and type 2 diabetes mellitus (DM), and 41 had ...