LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

α, β-Amyrin prevents steatosis and insulin resistance in a high-fat diet-induced mouse model of NAFLD via the AMPK-mTORC1-SREBP1 signaling mechanism

Lima, R P de; Nunes, P I G; Viana, A F S C; Oliveira, F T B de; Silva, R A C; Alves, A P N N; Viana, D A; Fonseca, S G C; Carvalho, A A; Chaves, M H; Rao, V S; Santos, F A.

Braz. j. med. biol. res; 54 (10), 2021

Nonalcoholic fatty liver disease (NAFLD), characterized by hepatosteatosis and steatohepatitis, is intrinsically related to obesity. Our previous study reported on the anti-obese activity of α,β-amyrin (AMY), a pentacyclic triterpene isolated from Protium heptaphyllum. This study investigated i...

Proteínas Quinasas Activadas por AMP, Dieta Alta en Grasa/efectos adversos, Resistencia a la Insulina, Hígado, Diana Mecanicista del Complejo 1 de la Rapamicina, Ratones Endogámicos C57BL, Enfermedad del Hígado Graso no Alcohólico/tratamiento farmacológico, Enfermedad del Hígado Graso no Alcohólico/prevención & control, Ácido Oleanólico/análogos & derivados, Proteína 1 de Unión a los Elementos Reguladores de Esteroles

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Pharmacological inhibition of mTORC1 activity protects against inflammation-induced apoptosis of nucleus pulposus cells

Chen, Rigao; Yang, Fei; Wang, Yong; Wang, Xinling; Fan, Xiaohong.

Braz. j. med. biol. res; 54 (5), 2021

Lumbar disc herniation is a common disease characterized by the degeneration of intervertebral discs (IVDs), accompanied by imbalance of metabolic and inflammatory homeostasis. Current studies establish that IVD degeneration is induced by increased apoptosis of nucleus pulposus (NP) cells. However, the u...

Apoptosis, Inflamación/tratamiento farmacológico, Degeneración del Disco Intervertebral/tratamiento farmacológico, Diana Mecanicista del Complejo 1 de la Rapamicina, Núcleo Pulposo

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Regulation of adiposity by mTORC1

Magdalon, Juliana; Festuccia, William Tadeu.

Einstein (Säo Paulo); 15 (4), 2017

ABSTRACT Obesity is characterized by an excessive increase in the adipose tissue mass, and is associated with higher incidence of several chronic metabolic diseases, such as type 2 diabetes. Therefore, its increasing prevalence is a public health concern, and it is important to better understand its etio...

Adipocitos/metabolismo, Tejido Adiposo Pardo/metabolismo, Tejido Adiposo Blanco/metabolismo, Adiposidad/fisiología, Diabetes Mellitus Tipo 2/metabolismo, Metabolismo de los Lípidos/fisiología, Diana Mecanicista del Complejo 1 de la Rapamicina/fisiología, Obesidad/metabolismo, Termogénesis/fisiología

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