La enfermedad de hígado graso no alcohólico (EHGNA) abarca desde
una acumulación simple de lípidos neutros, triacilglicéridos (TAG) y colesterol en más
del 5% de los hepatocitos, hasta una forma más avanzada llamada esteatohepatitis
no alcohólica (EHNA), la que incluye inflamación lobular, balon...
SUMMARY: The therapeutic effect of a granulocyte-colony stimulating factor (G-CSF) biosimilar drug, zarzio, on non-alcoholic fatty liver disease (NAFLD) in a rat model was investigated in this study. Thirty-two rats were randomly divided into four groups. Groups I and II were fed a standard laboratory di...
Factor Estimulante de Colonias de Granulocitos/administración & dosificación,
Biosimilares Farmacéuticos/administración & dosificación,
Enfermedad del Hígado Graso no Alcohólico/tratamiento farmacológico,
Modelos Animales de Enfermedad,
Inmunohistoquímica,
Factor de Necrosis Tumoral alfa/efectos de los fármacos,
Células Secretoras de Insulina/efectos de los fármacos,
Factor 2 Relacionado con NF-E2,
d0009750,
Dieta Alta en Grasa/efectos adversos,
Caspasa 3
A obesidade está associada ao desenvolvimento de doenças crônicas não transmissíveis como hipertensão, resistência insulínica, dislipidemia e esteatose hepática. O consumo de compostos bioativos impacta na manutenção da saúde e na prevenção de risco de desenvolvimento dessas doenças. Entre...
Liaqat, I;
Ali, N M;
Arshad, N;
Sajjad, S;
Rashid, F;
Hanif, U;
Ara, C;
Ulfat, M;
Andleeb, S;
Awan, U F;
Bibi, A;
Mubin, M;
Ali, S;
Tahir, H M;
ul-Haq, I.
Abstract The study was aimed to assess impact of high fat diet (HFD) and synthetic human gut microbiota (GM) combined with HFD and chow diet (CD) in inducing type-2 diabetes (T2D) using mice model. To our knowledge, this is the first study using selected human GM transplantation via culture based method ...
Disbiosis,
Dieta Alta en Grasa/efectos adversos,
Diabetes Mellitus Tipo 2,
Bacteroidetes,
Bacteroides,
Microbioma Gastrointestinal,
Inflamación,
Ratones Endogámicos C57BL,
Prevotella,
ARN Ribosómico 16S/genética,
Ruminococcus
Abstract Consuming a high-fat diet causes a harmful accumulation of fat in the liver, which may not reverse even after switching to a healthier diet. Different reports dealt with the role of purslane as an extract against high-fat diet; meanwhile, it was necessary to study the potential role of fresh pur...
Santos, L S;
Matos, R J B;
Cordeiro, G S;
Perez, G S;
Santo, D A E;
Silva, R T;
Gonçalves, M S;
Boaventura, G T;
Deiró, T C B J;
Barreto-Medeiros, J M.
Exposure to the hight-fat diet may alter the control of food intake promoting hyperphagia and obesity. The objective of this study was to investigate the effects of this diet on dopamine receptors (drd1 and drd2), proopiomelanocortin (pomc), neuropeptideY (npy) genes expression, and preference food in ad...
The inverse relationship between HDL-C (high-density lipoprotein cholesterol) and cardiovascular disease is well established. However, it is consensus that the cholesterol content present in HDL does not capture its complexity, and other metrics need to be explored. HDL is a heterogeneous, protein-enrich...
Brahmi, N;
Feriani, A;
Ben Ali, M;
Hedfi, A;
Elleuch, A;
Ismail, I A;
Albogami, B;
Saif, T;
Talarmin, H;
El Feki, A;
Allagui, M S.
The current investigation was carried out to estimate the protective effect of aqueous extract of Cheatomorpha gracilis (AEC) against High fat Diet (HFD) induced liver damage in mice. The results of the in vitro study showed that AEC have higher antioxidant capacities in the DPPH and hydroxyl radical-sca...
Siqueira, Juliana Silva;
Francisqueti-Ferron, Fabiane Valentini;
Garcia, Jéssica Leite;
Silva, Carol Cristina Vágula de Almeida;
Costa, Mariane Róvero;
Nakandakare-Maia, Erika Tiemi;
Moreto, Fernando;
Ferreira, Ana Lúcia A.;
Minatel, Igor Otávio;
Ferron, Artur Junio Togneri;
Corrêa, Camila Renata.
Abstract Introduction: Obesity, diabetes, and hypertension are common risk factors for chronic kidney disease (CKD). CKD arises due to many pathological insults, including inflammation and oxidative stress, which affect renal function and destroy nephrons. Rice bran (RB) is rich in vitamins and minerals...
ABSTRACT Purpose: To evaluate the morphological, biochemical, and histological effects of aqueous extracts of peanut (skinless and added to 1% skin) in Swiss mice submitted to a high-fat diet. Methods: Forty male Swiss mice were divided into four groups (n=10 per group): GI) normocaloric diet; GII) hig...
