Background: The therapeutic use of gingival mesenchymal stem cells (GMSCs) as autologous cells may pose the challenge of alterations inflicted by the hyperglycemic environment. Objective: This study aims to assess the effects of hyperglycemia on the characteristics of GMSCs in diabetics. Materials and Me...
SUMMARY: Senile osteoporosis is mainly caused by reduced osteoblast differentiation and has become the leading cause of fractures in the elderly worldwide. Natural organics are emerging as a potential option for the prevention and treatment of osteoporosis. This study was designed to study the effect of ...
Resveratrol/administración & dosificación,
Resveratrol/farmacología,
Osteoporosis/tratamiento farmacológico,
Diferenciación Celular/efectos de los fármacos,
Células Madre Mesenquimatosas/efectos de los fármacos,
Células Madre Mesenquimatosas/citología,
Sirtuina 1,
Modelos Animales de Enfermedad,
Western Blotting,
Ratones Endogámicos C57BL,
Osteogénesis/efectos de los fármacos
Abstract Mammals have a limited capacity to regenerate their tissues and organs. One of the mechanisms associated with natural regeneration is dedifferentiation. Several small molecules such as vitamin C and growth factors could improve reprogramming efficiency. In this study, the NTERA2-D1 (NT2) cells w...
BACKGROUND: Fibrous scars frequently form at the sites of bone nonunion when attempts to repair bone fractures have failed. However, the detailed mechanism by which fibroblasts, which are the main components of fibrous scars, impede osteogenesis remains largely unknown. RESULTS: In this study, we found t...
El presente trabajo muestra la obtención de un material a partir de un polímero sintético (TerP) y otro natural, mediante entrecruzamiento físico y su caracterización fisicoquímica y biológica, con el fin de emplearlos para regeneración de tejido óseo. Las membranas fueron obtenidas por l...
Cromatografía en Gel,
Diferenciación Celular,
Ensayo de Materiales,
Espectroscopía Infrarroja por Transformada de Fourier,
Huesos/química,
Materiales Biocompatibles/síntesis química,
Materiales Biocompatibles/toxicidad,
Osteogénesis,
Polímeros/química,
Polímeros/toxicidad,
Quitosano/química,
Quitosano/toxicidad,
Regeneración Ósea,
Resonancia Magnética Nuclear Biomolecular,
Técnicas de Cultivo de Célula
Abbas, S R;
Khan, R T;
Shafique, S;
Mumtaz, S;
Khan, A A;
Khan, A M;
Hassan, Z;
Hussain, S A;
Abbas, S;
Abbas, M R;
Batool, A;
Safder, M A.
Abstract By applying the in-silico method, resveratrol was docked on those proteins which are responsible for bone loss. The Molecular docking data between the resveratrol and Receptor activator of nuclear factor-kappa-Β ligand [RANKL] receptors proved that resveratrol binds tightly to the receptors...
BACKGROUND: Satellite cells are tissue-specific stem cells primarily responsible for the regenerative capacity of skeletal muscle. Satellite cell function and maintenance are regulated by extrinsic and intrinsic mechanisms, including the ubiquitin-proteasome system, which is key for maintaining protein h...
BACKGROUND: The distinct arterial and venous cell fates are dictated by a combination of various genetic factors which form diverse types of blood vessels such as arteries, veins, and capillaries. We report here that YULINK protein is involved in vasculogenesis, especially venous formation. METHODS: In t...
BACKGROUND: Knowledge about regulating transcription factors (TFs) for osteoblastogenesis from mesenchymal stem cells (MSCs) is limited. Therefore, we investigated the relationship between genomic regions subject to DNA-methylation changes during osteoblastogenesis and the TFs known to directly interact ...
Li, Ni;
Dai, Xiaofeng;
Yang, Fei;
Sun, Yang;
Wu, Xingwen;
Zhou, Qianrong;
Chen, Kai;
Sun, Jian;
Bi, Wei;
Shi, Le;
Yu, Youcheng.
BACKGROUND: Spontaneous spheroid culture is a novel three-dimensional (3D) culture strategy for the rapid and efficient selection of progenitor cells. The objectives of this study are to investigate the pluripotency and differentiation capability of spontaneous spheroids from alveolar bone-derived mesenc...
