LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Optimization of Diltiazem hydrochloride osmotic formulation using QBD approach

Joshi, Manjusha; Gokhale, Chinmay; Kenjale, Prathmesh; Pokharkar, Varsha.

Braz. J. Pharm. Sci. (Online); 58 (), 2022

Abstract Diltiazem hydrochloride (DLH) is a calcium channel blocker useful for the treatment of angina pectoris, arrhythmia, and hypertension. DLH having a short half-life needs frequent administration for successful treatment but this poses a problem of poor patient compliance. These requirements are se...

Bloqueadores de los Canales de Calcio/administración & dosificación, Cinética, Comprimidos, Diltiazem/análisis, Gestión de la Calidad Total/clasificación, Industria Farmacéutica/clasificación, Semivida, Métodos, Organización y Administración, Necesidades y Demandas de Servicios de Salud, Tamizaje Masivo, Sistemas de Liberación de Medicamentos

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Pharmacokinetics of diltiazem hydrochloride delay-onset sustained-release pellet capsules in healthy volunteers

Yan, Xi-Qing; Chen, Zhi-Gang; Wang, Rong-Liang; Yang, Jun; Ai, Fang; Pan, Yan-Juan; Qiu, Pei-Yong; Wang, Da-Xin.

Braz. j. pharm. sci; 49 (1), 2013

The pharmacokinetics (PK) of ordinary tablets and sustained release capsules of diltiazem hydrochloride in human clinical trials had been studied. The PK of diltiazem hydrochloride delay-onset sustained-release pellet capsules, a new dosage form, has not been reported, although it is very important to cl...

Farmacocinética, Cápsulas/análisis, Diltiazem/análisis, Voluntarios Sanos/clasificación, Ligamento Colateral Cubital, Cromatografía Líquida de Alta Presión/métodos

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Biodegradable microparticulate drug delivery system of diltiazem HCl

Gupta, Manish Kumar; Prakash, Deepak; Mishra, Brahmeshwar.

Braz. j. pharm. sci; 48 (4), 2012

The efficacy of a drug in a specific application requires the maintenance of appropriate drug blood level concentration during a prolonged period of time. Controlled release delivery is available for many routes of administration and offers many advantages (as microparticles and nanoparticles) over immed...

Liberación de Fármacos, Diltiazem/análisis, Albúminas/farmacocinética, Cinética

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Formulation and in vitro evaluation of taste-masked oro-dispersible dosage form of diltiazem hydrochloride

Jagdale, Swati Changdeo; Gawali, Vaibhav Uttam; Kuchekar, Bhanudas Shankar; Chabukswar, Aniruddha Rajaram.

Braz. j. pharm. sci; 47 (4), 2011

Diltiazem hydrochloride is a calcium channel blocker generally indicated for the treatment of angina and hypertension, and it is extensively metabolized due to the hepatic metabolism. Formulation of diltiazem hydrochloride into an oro-dispersible dosage form can provide fast relief with higher bioavailab...

Formas de Dosificación, Diltiazem/análisis, Ciclodextrinas, Liofilización/22074, Comprimidos/clasificación, Enmascaramiento Perceptual

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