Aim: Cyclooxygenase enzymes (COX) catalyze the conversion of arachidonic acid to prostaglandins and thromboxanes during pain and inflammation conditions. These enzymes have also been linked to several other conditions and diseases, and hence, in dentistry, it is crucial to identify the processes that inc...
Barbosa, Thiago Antunes da Silva;
Freitas, Iuri Dornelas Prates;
Senna, Sarah Mattos Ferreira;
Costa, Laila Gabriela de Figueiredo;
Ribeiro, Milena Carvalho Tourino;
Silva Júnior, Wanderson Ferreira da;
Lima, Stela Occhi Siqueira;
Gonçalves, Alice Soares;
Monteiro, Juliana de Sousa;
Carvalho, Luiz Paulo Rocha;
Amormino, Simone Angélica de Faria.
Introdução: A Doença Periodontal tem caráter multifatorial, já que depende de condições microbiológicas, imunogenéticas e sistêmicas do hospedeiro. Representa inflamação crônica das estruturas de suporte e proteção dental. Desencadeia uma complexa estimulação imunológica, bem como a pro...
Enfermedades Periodontales/terapia,
Enfermedades Periodontales,
Doxiciclina,
Metaloproteinasas de la Matriz,
Inhibidores de la Metaloproteinasa de la Matriz,
Periodontitis,
Probióticos,
Ácidos Grasos Omega-3,
Aspirina,
Dinoprostona,
Prostaglandinas E
Abstract To explore the effects and mechanisms of benzoylaconitine and paeoniflorin on collagen-induced arthritis (CIA) rats. Weight, paw swelling, arthritis index and joint pathologic changes were examined in each group after CIA induction. PGE2, IL-1β, IL-6, IL-10, TNF-α, VEGF, MMP-3, IgG and anti-CI...
ABSTRACT Soft tissue injury is the most common disease in orthopedics, and it is also the most easily neglected disease in sports. Without timely and effective treatment, it is easy to develop into malignant strain and seriously affect life and sports. In view of this, the aim of this study is to analyze...
The objective of this study was to determine the ability of prostaglandin E2 (PGE2) to induce ovulation and expression of PGE2 receptor (EP2 and EP4) and COX genes (COX-1 and COX-2) in the ovary and pituitary of prepubertal mice. The positive control consisted of the application of 5 μg of gonadotropin-...
INTRODUCCIÖN Y OBJETIVOS: Describir la experiencia de los partos en gestantes con diagnóstico confirmado de COVID 19 mediante RT-PCR asintomáticas o con sintomatología leve y aquellas sin la enfermedad, y determinar la tasa de éxito de parto vaginal en inducción de trabajo de parto. MÉTODOS: Aná...
Trabajo de Parto Inducido/métodos,
Infecciones por Coronavirus/complicaciones,
Neumonía Viral/complicaciones,
Pandemias,
Betacoronavirus,
Estudios Retrospectivos,
Resultado del Embarazo,
Dinoprostona/administración & dosificación,
Oxitocina/administración & dosificación,
Cesárea,
Parto Obstétrico,
Complicaciones Infecciosas del Embarazo/terapia,
Complicaciones Infecciosas del Embarazo/virología
Abstract Purpose To evaluate the kinetics of apical periodontitis development in vivo , induced either by contamination of the root canals by microorganisms from the oral cavity or by inoculation of bacterial lipopolysaccharide (LPS) and the regulation of major enzymes and receptors involved in the arac...
Araquidonato 5-Lipooxigenasa/análisis,
Araquidonato 5-Lipooxigenasa/metabolismo,
Resorción Ósea/metabolismo,
Resorción Ósea/microbiología,
Ciclooxigenasa 2/análisis,
Ciclooxigenasa 2/metabolismo,
Cavidad Pulpar/metabolismo,
Cavidad Pulpar/microbiología,
Cavidad Pulpar/patología,
Dinoprostona/análisis,
Dinoprostona/metabolismo,
Expresión Génica,
Leucotrieno B4/análisis,
Leucotrieno B4/metabolismo,
Lipopolisacáridos/metabolismo,
Ratones Endogámicos C57BL,
Periodontitis Periapical/metabolismo,
Periodontitis Periapical/microbiología,
Periodontitis Periapical/patología,
ARN Mensajero/análisis,
ARN Mensajero/metabolismo,
Distribución Aleatoria,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Factores de Tiempo
Oxidative stress and inflammation are the key players in the development of motor dysfunction post-spinal cord ischemic reperfusion injury (SC-IRI). This study investigated the protective effect of concomitant pre-administration of melatonin and alpha-tocopherol on the early complications (after 48 hours...
Melatonina/administración & dosificación,
Estrés Oxidativo/efectos de los fármacos,
Isquemia de la Médula Espinal/tratamiento farmacológico,
Melatonina/farmacología,
Tocoferoles/farmacología,
Daño por Reperfusión/tratamiento farmacológico,
Antioxidantes/administración & dosificación,
Antioxidantes/farmacología,
Nitritos/sangre,
Médula Espinal/patología,
Médula Espinal/efectos de los fármacos,
Paraplejía,
Dinoprostona/sangre,
Ratas Sprague-Dawley
Abstract Prostaglandin E2 (PGE2) is a lipid mediator usually released during inflammation. This study aimed to investigate the potential of soluble or microsphere-loaded PGE2 on inducing differentiation of dental pulp stem cells. PGE2-loaded microspheres (MS) were prepared using an oil-in-water emulsion ...
Many compounds of ginsenosides show anti-inflammatory properties. However, their anti-inflammatory effects in intervertebral chondrocytes in the presence of inflammatory factors have never been shown. Increased levels of pro-inflammatory cytokines are generally associated with the degradation and death o...
Agrecanos/metabolismo,
Supervivencia Celular/efectos de los fármacos,
Condrocitos/citología,
Condrocitos/efectos de los fármacos,
Condrocitos/metabolismo,
Ciclooxigenasa 2/metabolismo,
Dinoprostona/metabolismo,
Ginsenósidos/metabolismo,
Ginsenósidos/farmacología,
Inflamación/metabolismo,
Proteína Accesoria del Receptor de Interleucina-1/metabolismo,
Interleucina-1beta/efectos de los fármacos,
Interleucina-1beta/metabolismo,
Degeneración del Disco Intervertebral/metabolismo,
Dolor de la Región Lumbar/metabolismo,
Óxido Nítrico Sintasa/metabolismo,
Núcleo Pulposo/citología,
Núcleo Pulposo/efectos de los fármacos,
Núcleo Pulposo/metabolismo,
Factor de Necrosis Tumoral alfa/metabolismo,
Ubiquitinación
