LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Knockdown of lncRNA TUG1 inhibits hippocampal neuronal apoptosis and participates in aerobic exercise-alleviated vascular cognitive impairment

Wang, Jing; Niu, Yali; Tao, Huaying; Xue, Mina; Wan, Chunxiao.

Biol. Res; 53 (), 2020

OBJECTIVES: Our previous study indicated that aerobic exercise relieves cognitive impairment in patients with vascular cognitive impairment (VCI) via regulating brain-derived neurotrophic factor (BDNF), but the mechanism is not yet clear. This study aimed to explore whether lncRNA taurine upregulated gen...

Apoptosis, Disfunción Cognitiva/genética, Disfunción Cognitiva/terapia, Neuronas/patología, ARN Largo no Codificante/genética, Condicionamiento Físico Animal, Factor Neurotrófico Derivado del Encéfalo, Línea Celular, Proliferación Celular, Técnicas de Silenciamiento del Gen, Hipocampo/citología, Ratones Endogámicos C57BL, Ratones Noqueados, ARN Largo no Codificante/sangre, Taurina

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Exploratory analysis of rare and novel variants in Mexican patients diagnosed with schizophrenia and dementia

Martínez-Magaña, José J.; Genís-Mendoza, Alma D.; González-Covarrubias, Vanessa; Jiménez-Guenchi, Janet; Galindo-Chávez, Aidé G.; Roche-Bergua, Andrés; Castañeda-González, Carlos; Lanzagorta, Nuria; Soberón, Xavier; Nicolini, Humberto.

Rev. invest. clín; 71 (4), 2019

Abstract Background Schizophrenia (SCZ) and dementia, often related, are two of the most common neuropsychiatric diseases; epidemiological studies have shown that SCZ patients present a 2-fold increased risk for dementia compared to non-schizophrenic individuals. We explored the presence of rare and nov...

Enfermedad de Alzheimer/genética, Enfermedad de Alzheimer/fisiopatología, Disfunción Cognitiva/genética, Disfunción Cognitiva/fisiopatología, Demencia/genética, Demencia/fisiopatología, Variación Genética, Secuenciación de Nucleótidos de Alto Rendimiento, México, Proteínas Asociadas a Resistencia a Múltiples Medicamentos/genética, Fenotipo, Esquizofrenia/genética, Esquizofrenia/fisiopatología

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Association between BDNF G196A (Val66Met) polymorphism and cognitive impairment in patients with Parkinson's disease: a meta-analysis

Wang, Qian; Liu, Jianfang; Guo, Yikun; Dong, Guanzhong; Zou, Wenying; Chen, Zhuoyou.

Braz. j. med. biol. res; 52 (8), 2019

Brain-derived neurotrophic factor (BDNF) is widely expressed in the central nervous system and prolongs the survival of dopaminergic neurons in the substantia nigra. Several studies have recently investigated the association between BDNF G196A (Val66Met), a single nucleotide polymorphism influencing cogn...

Enfermedad de Alzheimer/complicaciones, Factor Neurotrófico Derivado del Encéfalo/genética, Estudios de Casos y Controles, Disfunción Cognitiva/complicaciones, Disfunción Cognitiva/genética, Población Blanca, Predisposición Genética a la Enfermedad, Genotipo, Oportunidad Relativa, Enfermedad de Parkinson/complicaciones, Enfermedad de Parkinson/genética, Polimorfismo de Nucleótido Simple, Factores de Riesgo

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BsmI polymorphism in the vitamin D receptor gene is associated with 25-hydroxy vitamin D levels in individuals with cognitive decline

Oliveira, Ana Carolina R de; Magalhães, Carolina A; Loures, Cristina M G; Fraga, Vanessa G; Souza, Leonardo C de; Guimarães, Henrique C; Cintra, Marco T G; Bicalho, Maria A; Sousa, Maira C R; Silveira, Josianne N; Silva, Ieda F O; Caramelli, Paulo; Carvalho, Maria G; Gomes, Karina B.

Arq. neuropsiquiatr; 76 (11), 2018

ABSTRACT Elderly people are at a high risk of developing vitamin D (VitD) deficiency due to both decreased intake and cutaneous synthesis. Most of the biological actions of VitD are mediated by the vitamin D receptor (VDR), which is present in neurons and glial cells of the hippocampus, and in the cortex...

Distribución por Edad, Estudios de Casos y Controles, Disfunción Cognitiva/genética, Disfunción Cognitiva/fisiopatología, Expresión Génica, Polimorfismo de Nucleótido Simple/genética, Receptores de Calcitriol/genética, Distribución por Sexo, Vitamina D/análogos & derivados, Vitamina D/sangre

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