LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Spray-dried co-amorphous Tadalafil ternary mixtures: a promising platform towards the enhancement of solubility and bioavailability

El-Maradny, Hoda; Saab, May.

Braz. J. Pharm. Sci. (Online); 58 (), 2022

Abstract Tadalafil (Tad) is a poorly water-soluble drug (BCS class II) that is used for the treatment of erectile dysfunction. An enhancement of aqueous solubility is vital to accelerate its onset of action and subsequently enhance its therapeutic effect. Binary and ternary mixtures of Tad with different...

Tadalafilo/análisis, Solubilidad, Disfunción Eréctil/patología, d0045260, ddcs0285700, Preparaciones Farmacéuticas/análisis

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Morphological and molecular analysis of apoptosis in the corpus cavernosum of rats submitted to a chronic alcoholism model

Meirelles, Rogério José de Azevedo; Lizarte Neto, Fermino Sanches; Cirino, Mucio Luiz de Assis; Novais, Paulo Cezar; Gula, Isabella Stracieri; Silva, Jairo Pinheiro da; Tazzima, Maria de Fátima Galli Sorita; Fazan, Valéria Paula Sassoli; Durand, Marina Toledo; Tirapelli, Daniela Pretti da Cunha; Carvalho, Camila Albuquerque Melo de; Schimming, Bruno César; Molina, Carlos Augusto Fernandes; Tucci Junior, Silvio; Tirapelli, Luis Fernando.

Acta cir. bras; 35 (3), 2020

Abstract Purpose To evaluate the effect of chronic alcoholism on morphometry and apoptosis mechanism and correlate with miRNA-21 expression in the corpus cavernosum of rats. Methods Twenty-four rats were divided into two experimental groups: Control (C) and Alcoholic group (A). After two weeks of an ...

Alcoholismo/complicaciones, Apoptosis/efectos de los fármacos, Caspasa 3/análisis, Modelos Animales de Enfermedad, Disfunción Eréctil/inducido químicamente, Disfunción Eréctil/patología, Expresión Génica, Inmunohistoquímica, MicroARNs/análisis, Músculo Liso/efectos de los fármacos, Pene/efectos de los fármacos, Pene/patología, Ratas Wistar, Valores de Referencia

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The relationship between histological prostatitis and lower urinary tract symptoms and sexual function

Kumsar, Sukru; Kose, Osman; Aydemir, Huseyin; Halis, Fikret; Gokce, Ahmet; Adsan, Oztug; Akkaya, Zeynep Kahyaoglu.

Int. braz. j. urol; 42 (3), 2016

ABSTRACT This prospective analysis assessed the effect of histological prostatitis on lower urinary tract functions and sexual function. The patients were separated into two groups as histologically observed prostatitis (Group A) and no prostatitis (Group B) according to the biopsy outcomes. Internationa...

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