Abstract The aim of this study was to compare the dissolution properties of ibuprofen solid oral dosage forms commercially available in Bosnia and Herzegovina and to estimate the influence of dissolution medium composition on the drug release. Eight products (A-H) were subjected to in vitro dissolution t...
Abstract Albendazole is an anthelmintic drug commonly used in parenchymal neurocysticercosis and cystic echinococcosis. The aim of this study was to explore whether disparities in the dissolution profiles of albendazole products lead to significant differences in pharmacokinetic parameters. Three generic...
Abstract This study aimed to develop and evaluate the stability of sulfadiazine sugar-free extemporaneous oral suspensions, focusing on treating congenital toxoplasmosis. The excipients were carefully chosen to obtain safe products for the pediatric population. Sulfadiazine suspensions (100 mg/ mL) were ...
Achyrocline satureioides is popularly known for its richness in phenolic compounds and medicinal properties (anti-inflammatory, analgesic, and hepatoprotective). The present study aimed at broadening the knowledge about the pharmacological potential exerted by the aqueous and ethanolic extracts of A. sat...
The purpose of this work was to elaborate a diagnosis of the dissolution test in Africa in comparison with Brazil, evaluating the dissolution profile of low solubility drugs such as albendazole, ibuprofen, furosemide, glibenclamide, hydrochlorothiazide and carvedilol to ascertain their quality. The disso...
Disolución,
África/etnología,
Brasil/etnología,
Preparaciones Farmacéuticas/análisis,
Solubilidad,
Carvedilol/farmacología,
Albendazol/farmacología,
Acetatos/efectos adversos,
Furosemida/farmacología,
Ibuprofeno,
Métodos,
United States Food and Drug Administration
O organogel é formado por uma matriz tridimensional composta de filamentos que se auto-organizam em uma rede entrelaçada e que, por seu tipo de estrutura, pode ser utilizado com o objetivo de atuar como um implante que se forma in situ, sendo capaz de se comportar como uma forma farmacêutica de libera...
Disolución,
Poloxámero/análisis,
Lecitinas/análisis,
Meloxicam/antagonistas & inhibidores,
Drogas Veterinarias/análisis,
Cromatografía Liquida/métodos,
Cromatografía Líquida de Alta Presión/métodos,
Farmacéuticos/clasificación,
Formas de Dosificación,
Veterinarios,
Métodos,
Preparaciones Farmacéuticas/análisis,
Química Farmacéutica/instrumentación
For a drug to excerpt pharmacological action after oral intake, it first needs to be released from the formulation, get into solution (dissolve), be absorbed, and reach the systemic circulation. Since only solubilized drugs can be absorbed, and thus have therapeutic effect, the understanding of the disso...
Optimización de Procesos,
Acciones Farmacológicas,
Composición de Medicamentos,
Concentración de Iones de Hidrógeno,
Desarrollo de Medicamentos/instrumentación,
Eficiencia,
Liberación de Fármacos,
Metronidazol/efectos adversos,
Necesidades y Demandas de Servicios de Salud/clasificación,
Preparaciones Farmacéuticas/análisis,
Química Farmacéutica/instrumentación,
Disolución
A conjuntivite bacteriana tem significante impacto na Saúde Pública. Essa infecção representa mais de um terço das doenças oculares relatadas em âmbito global. É uma doença altamente contagiosa causada por variedade de bactérias aeróbias e anaeróbias. Diferentes antibióticos empregados no tr...
Conjuntivitis Bacteriana/metabolismo,
Nanopartículas/análisis,
Fluoroquinolonas,
Antibacterianos/clasificación,
Cromatografía Líquida de Alta Presión/métodos,
Bacterias Aerobias/clasificación,
Disolución,
Química Física/instrumentación,
Infecciones/tratamiento farmacológico,
Oftalmopatías/patología,
Preparaciones Farmacéuticas,
Química Farmacéutica,
Técnicas In Vitro/instrumentación
Abstract Efavirenz is one of the most commonly used drugs in HIV therapy. However the low water solubility tends to result in low bioavailability. Drug nanocrystals, should enhance the dissolution and consequently bioavailability. The aim of the present study was to obtain EFV nanocrystals prepared by an...
Nanopartículas/administración & dosificación,
Cristalización/instrumentación,
Disolución/métodos,
Eficacia/clasificación,
Excipientes/farmacología,
VIH/patogenicidad,
Métodos,
Preparaciones Farmacéuticas/administración & dosificación,
Solubilidad,
Tamaño de la Partícula,
Disolución/clasificación
Abstract Compounding pharmacies play an important role not only in compounding personalized formulations, but also preparing drugs at the same concentration and dosage as those from commercial manufacturers. The excipients used in compounding are generally standardized for many drugs, however they do not...
