LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Duchenne muscular dystrophy: an historical treatment review

Werneck, Lineu Cesar; Lorenzoni, Paulo José; Ducci, Renata Dal-Prá; Fustes, Otto Hernández; Kay, Cláudia Suemi Kamoi; Scola, Rosana Herminia.

Arq. neuropsiquiatr; 77 (8), 2019

ABSTRACT In this review, we discuss the therapies used in the treatment of patients with Duchenne muscular dystrophy since the first description of the disease. A short description is given of the various theories based on disease pathogenesis, which give the substrates for the many therapeutic intervent...

Corticoesteroides/uso terapéutico, Antiinflamatorios/uso terapéutico, Antioxidantes/uso terapéutico, Bloqueadores de los Canales de Calcio/uso terapéutico, Inhibidores de la Colinesterasa/uso terapéutico, Distrofina/efectos de los fármacos, Distrofina/metabolismo, Distrofia Muscular de Duchenne/tratamiento farmacológico, Distrofia Muscular de Duchenne/metabolismo

Fulltext

Low intensity training provokes adaptations on muscle fibrosis of a muscular dystrophy model

Duchenne muscular dystrophy (DMD) is a genetic neuromuscular disorder with progressive clinical signs until death, around the second decade of life. Mdx is the most used animal model to pre-clinical studies of DMD. Parameters of exercise on this muscular disease are still unknown. This research aimed to ...