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Cerebrospinal fluid-contacting nucleus mediates nociception via release of fractalkine

Braz. j. med. biol. res; 50 (9), 2017
Increasing evidence suggests that the cerebrospinal fluid-contacting nucleus (CSF-contacting nucleus) mediates the transduction and regulation of pain signals. However, the precise molecular mechanisms remain unclear. Studies show that release of fractalkine (FKN) from neurons plays a critical role...