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Rational drug repurposing for alzheimer's treatment using in-silico ligand and structure-based approaches

Rathi, Karishma; Wavhale, Ravindra; Bhole, Ritesh; Undale, Vaishali; Chaudhari, Somdatta.
Braz. J. Pharm. Sci. (Online); 60 (), 2024
Abstract Alzheimer's disease is a devastating neurodegenerative disorder characterized by memory loss and cognitive decline. New AD treatments are essential, and drug repositioning is a promising approach. In this study, we combined ligand-based and structure-based approaches to identify potential candid...
Preparaciones Farmacéuticas/clasificación, Enfermedad de Alzheimer/patología, Reposicionamiento de Medicamentos/clasificación, Donepezilo/agonistas, Enfermedades Neurodegenerativas/clasificación, d0105990, Preparaciones Farmacéuticas/análisis
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Micro and nanocrystalline cellulose based oral dispersible film; preparation and evaluation of in vitro/in vivo rapid release studies for donepezil

AnjiReddy, Keshireddy; Karpagam, Subramanian.
Braz. J. Pharm. Sci. (Online); 56 (), 2020
Oral fast-dispersible film was prepared by utlizing donepezil hydrochloride (drug) and various cellulose derivatives such as hydroxypropyl methyl cellulose (hypermellose) (HPMC), microcrystalline cellulose (MCC) and nanocrystalline cellulose (NCC) to treat Alzheimer's disease. NCC was synthesized by ultr...
Técnicas In Vitro/métodos, Donepezilo/agonistas, Enfermedad de Alzheimer/patología, Sonicación/métodos, Espectroscopía Infrarroja por Transformada de Fourier/métodos, Celulosa, Disolución/clasificación, Modelos Animales, Preparaciones Farmacéuticas/análisis
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