Bosanac, Milana;
Amidzic, Jelena;
Stefanovic, Maja;
Radic, Jelena;
Kolarov-Bjelobrk, Ivana;
Janicic, Stefan;
Gojkovic, Zdenka;
Lazic, Bojana;
Djokanovic, Dejan;
Misan, Aleksandra;
Cvetkovic, Biljana;
Stupar, Alena;
Martic, Nikola;
Andrejic-Visnjic, Bojana.
SUMMARY: Doxorubicin (DOX) is one of the drugs necessary for the treatment of the 10 most common types of cancer. The leading adverse effect limiting clinical use of DOX is cardiotoxicity. Given that literature data indicate a protective role of carotenoids in doxorubicin-induced toxicity, in our study w...
Cardiotoxicidad/prevención & control,
Cucurbita/química,
Carotenoides/administración & dosificación,
Doxorrubicina/toxicidad,
Antibióticos Antineoplásicos/toxicidad,
Neoplasias/tratamiento farmacológico,
Peroxidación de Lípido,
Catalasa,
Glutatión Transferasa,
Glutatión Peroxidasa,
Ratas Wistar,
Antioxidantes,
Estrés Oxidativo/efectos de los fármacos,
Cardiotónicos
Almeida, André Luiz Cerqueira de;
Santos Júnior, Edval Gomes dos;
Monteiro Neto, Aluísio José de Oliveira;
Espírito Santo, Thyago Monteiro do;
Almeida, Paulo André A;
Affonseca, Samuel Oliveira;
Almeida, Caroline de Souza;
Freitas, Matheus Pamponet;
Santos, Cecília Lopes Viana;
Ximenes, Vitória Régia Beserra Barbosa;
Falcão, Mariana Andrade;
Reis, Israel Costa;
Souza, Suzane Pereira de;
Serra, Maurício Gomes da Silva;
Oliveira, Ana Beatriz Menezes de;
Santos, Tayla Silva;
Lopes, Nilson Lima;
Melo, Marcelo Dantas Tavares de.
Background: The combination of doxorubicin (DOX) with paclitaxel (PTX) effectively treats breast cancer (BC). However, DOX-associated cardiotoxicity (CTX) is aggravated by the use of PTX. Consensus is lacking about which drug sequence involves the most CTX. Objectives: To evaluate whether DOX followed by...
Resumo Fundamento A doxorrubicina (DOX) é frequentemente usada para tratar muitos tipos de cânceres, apesar da cardiotoxicidade dose-dependente. Como alternativa, o resveratrol é um polifenol que tem demonstrado efeitos cardioprotetores em vários modelos de disfunção cardíaca. Objetivo Este estu...
Abstract The present study was aimed to investigate the in vivo effects of Rosa canina extract on doxorubicin-induced testicular toxicity in mice for the first time. Male NMRI mice were randomly divided into six treatment groups (10=per group) as follows: (I) vehicles, (II) doxorubicin alone (3 mg/kg, i....
SUMMARY: Doxorubicin is a drug that used by a majority in the treatment of carcinomas. The most obvious known side effect is cardiomyopathy. Many studies have been carried out to eliminate side effects of the doxorubicin, and stem cell studies have been added in recent years. In this study, it was aimed ...
Abstract Handroanthus impetiginosus has long been used in traditional medicine and various studies have determined the presence of bioactive chemical compounds and potential phytotherapeutics. In this study, the genotoxicity of the lyophilized tincture of H. impetiginosus bark (THI) was evaluated in mous...
Some studies have shown the role played by matrix metalloproteinases and their inhibitors in doxorubicin cardiotoxicity. In this study, we sought to investigate how plasma and myocardial MMP 2 and 9 perform in rabbits with doxorubicin-induced cardiomyopathy, searching for a correlation between the activi...
A doxorrubicina (DOX) é um quimioterápico utilizado no tratamento de neoplasias malignas, porém possui a cardiotoxicidade como efeito colateral. O objetivo deste trabalho foi verificar quanto à ação do extrato etanólico da casca do pequi (Caryocar brasiliense) (EECP) por meio de avaliação morfol...
Resumo Objetivo Obter o óleo do Astrocaryum aculeatum (A.a) e avaliar a genotoxidade/antigenotoxidade pelo teste do micronúcleo em células do sangue periférico. Métodos O óleo da A.a foi obtido por prensagem hidráulica. Os animais foram camundongos Swiss, machos e saudáveis com 6-7 semanas de...
