Home > LILACS - Literatura Latinoamericana y del Caribe de Ciencias de la Salud > Search result

Results: 2

Rapid and long-lasting antidepressant-like effects of ketamine and their relationship with the expression of brain enzymes, BDNF, and astrocytes

Viana, G S B; Vale, E M do; Araujo, A R A de; Coelho, N C; Andrade, S M; Costa, R O da; Aquino, P E A de; Sousa, C N S de; Medeiros, I S de; Vasconcelos, S M M de; Neves, K R T.
Braz. j. med. biol. res; 54 (2), 2021
Ketamine (KET) is an N-methyl-D-aspartate (NMDA) antagonist with rapid and long-lasting antidepressant effects, but how the drug shows its sustained effects is still a matter of controversy. The objectives were to evaluate the mechanisms for KET rapid (30 min) and long-lasting (15 and 30 days after) anti...
Antidepresivos/farmacología, Astrocitos, Encéfalo/efectos de los fármacos, Encéfalo/enzimología, Factor Neurotrófico Derivado del Encéfalo/metabolismo, Modelos Animales de Enfermedad, Proteína Ácida Fibrilar de la Glía, Glucógeno Sintasa Quinasa 3, Histona Desacetilasas, Ketamina/farmacología
Fulltext

Effects of Chronic Exposure to Mercury on Angiotensin-Converting Enzyme Activity and Oxidative Stress in Normotensive and Hypertensive Rats

Vassallo, Dalton Valentim; Simões, Maylla Ronacher; Giuberti, Karina; Azevedo, Bruna Fernandes; Ribeiro Junior, Rogerio Faustino; Salaices, Mercedes; Stefanon, Ivanita.
Arq. bras. cardiol; 112 (4), 2019
Abstract Background: Mercury's deleterious effects are associated with increased cardiovascular risk. Objective: To determine whether chronic exposure to inorganic mercury increases the activity of angiotensin-converting enzyme and its relationship with oxidative stress in several organs and tissues. ...
Aorta/enzimología, Presión Sanguínea/efectos de los fármacos, Encéfalo/enzimología, Corazón, Hipertensión/metabolismo, Hipertensión/fisiopatología, Riñón/enzimología, Pulmón/enzimología, Malondialdehído/sangre, Mercurio/toxicidad, Intoxicación por Mercurio/complicaciones, Estrés Oxidativo/efectos de los fármacos, Peptidil-Dipeptidasa A/análisis, Peptidil-Dipeptidasa A/efectos de los fármacos, Ratas Endogámicas SHR, Ratas Wistar, Valores de Referencia, Factores de Riesgo, Factores de Tiempo
Fulltext