Severe progressive brain involvement in a patient with TRMT10C mutation
Arq. neuropsiquiatr; 79 (3), 2021
Results: 22
Different expressions of AQP1 and AQP4 in hyponatremic rat brain
Int. j. morphol; 39 (1), 2021
SUMMARY: The expression of aquaporin-1 (AQP1) in choroid plexus and aquaporin-4 (AQP4) in astrocyte of the hippocampal formation (HF) was studied in the rat to determine the role of AQP1 and AQP4 in the pathophysiology of systemic hyponatremia (SH). SH was induced by coadministration of dextrose solution...
Blood-cerebrospinal fluid (CSF) barrier dysfunction means reduced CSF flow not barrier leakage - conclusions from CSF protein data
Arq. neuropsiquiatr; 79 (1), 2021
ABSTRACT Background: Increased concentrations of serum proteins in cerebrospinal fluid (CSF) are interpreted as blood-CSF barrier dysfunction. Frequently used interpretations such as barrier leakage, disruption or breakdown contradict CSF protein data, which suggest a reduced CSF flow rate as the cause...
Effects of oxidative stress on liver, brain and spinal cord of rats using L-NAME and treated with hydroxyurea. A model of sickle cell complication
Acta cir. bras; 35 (3), 2020
Abstract Purpose: To analyze the serum levels of nitric oxide and correlate them with the levels of thiobarbituric acid reactive substances (TBARS) in liver, brain and spinal cord of animals using L-NAME and treated with hydroxyurea. Methods: Eighteen male albino Wistar rats were divided into three gro...
Anemia de Células Falciformes/tratamiento farmacológico, Anemia de Células Falciformes/metabolismo, Anemia de Células Falciformes/fisiopatología, Encéfalo/metabolismo, Modelos Animales de Enfermedad, Hidroxiurea/uso terapéutico, Hígado/metabolismo, NG-Nitroarginina Metil Éster, Estrés Oxidativo/fisiología, Ratas Wistar, Médula Espinal/metabolismo
Aging and low-intensity exercise change oxidative biomarkers in brain regions and radiographic measures of femur of Wistar rats
Braz. j. med. biol. res; 53 (6), 2020
We investigated changes in oxidative biomarkers in brain regions such as brainstem, cerebellum, and cerebral cortex of 3-, 6-, 18-, 24-, and 30-month-old rats. We also assessed the effects of low-intensity exercise on these biomarkers in these regions of 6-, 18-, and 24-month-old rats that started exerci...
Envejecimiento/metabolismo, Envejecimiento/fisiología, Biomarcadores/análisis, Encéfalo/metabolismo, Fémur/química, Fémur/diagnóstico por imagen, Peroxidación de Lípido, Peróxidos Lipídicos/análisis, Oxidación-Reducción, Estrés Oxidativo/fisiología, Condicionamiento Físico Animal/fisiología, Ratas Wistar
Effects of growth hormone in the central nervous system
Arch. endocrinol. metab. (Online); 63 (6), 2019
ABSTRACT Growth hormone (GH) is best known for its effect stimulating tissue and somatic growth through the regulation of cell division, regeneration and proliferation. However, GH-responsive neurons are spread over the entire central nervous system, suggesting that they have important roles in the brain...
Adipose tissue is less responsive to food restriction anti-inflammatory effects than liver, muscle, and brain in mice
Braz. j. med. biol. res; 52 (1), 2019
High caloric intake promotes chronic inflammation, insulin resistance, and chronic diseases such as type-2 diabetes, which may be prevented by food restriction (FR). The effect of FR on expression of pro-inflammatory and anti-inflammatory genes in adipose tissue, liver, muscle, and brain was compared. Ma...
Comparison of different quantification methods for 18F-fluorodeoxyglucose-positron emission tomography studies in rat brains
Clinics; 74 (), 2019
OBJECTIVES: This study aimed to evaluate several methods to estimate glucose consumption in the male Wister rat brain as measured by PET. METHODS: Fourteen male Wistar normoglycemic rats were studied. The input function consisted of seventeen blood samples drawn manually from the femoral artery. Glucose...
Comparison among ACR1997, SLICC and the new EULAR/ACR classification criteria in childhood-onset systemic lupus erythematosus
Adv Rheumatol; 59 (), 2019
Abstract Background: To date there are no specific classification criteria for childhood-onset systemic lupus erythematosus (cSLE). This study aims to compare the performance among the American College of Rheumatology (ACR) 1997, the Systemic Lupus International Collaborating Clinics criteria (SLICC) an...
Barrera Hematoencefálica/metabolismo, Encéfalo/metabolismo, Modelos Teóricos, Preparaciones Farmacéuticas/metabolismo, Distribución Tisular/fisiología, Aracnoides/efectos de los fármacos, Aracnoides/metabolismo, Transporte Biológico/efectos de los fármacos, Transporte Biológico/fisiología, Barrera Hematoencefálica/efectos de los fármacos, Encéfalo/efectos de los fármacos, Líquido Extracelular/efectos de los fármacos, Líquido Extracelular/metabolismo, Preparaciones Farmacéuticas/administración & dosificación, Distribución Tisular/efectos de los fármacos
Effects of cerebral oxygen changes during coronary bypass surgery on postoperative cognitive dysfunction in elderly patients: a pilot study
Rev. bras. anestesiol; 68 (2), 2018
Abstract Background and objectives: Postoperative cognitive dysfunction is common after cardiac surgery. Adequate cerebral perfusion is essential and near infrared spectroscopy (NIRS) can measure cerebral oxygenation. Aim of this study is to compare incidence of early and late postoperative cognitive dy...
Encéfalo/metabolismo, Disfunción Cognitiva/epidemiología, Disfunción Cognitiva/terapia, Puente de Arteria Coronaria, Incidencia, Persona de Mediana Edad, Monitoreo Intraoperatorio, Oxígeno/metabolismo, Proyectos Piloto, Complicaciones Posoperatorias/epidemiología, Complicaciones Posoperatorias/terapia, Espectroscopía Infrarroja Corta, Factores de Tiempo