Abstract Objective Abnormalities in the eutopic endometrium of women with endometriosis may be related to disease-associated infertility. Although previous RNA-sequencing analysis did not show differential expression in endometrial transcripts of endometriosis patients, other molecular alterations coul...
Estudios de Casos y Controles,
Simulación por Computador,
Implantación del Embrión,
Endometriosis/complicaciones,
Endometriosis/genética,
Endometrio/metabolismo,
Infertilidad Femenina/etiología,
Infertilidad Femenina/metabolismo,
Mutación,
Estudios Prospectivos,
Receptores de Quimiocina/genética,
Análisis de Secuencia de ARN
The long noncoding RNA (lncRNA) H19 is involved in the pathogenesis of endometriosis by modulating the proliferation and invasion of ectopic endometrial cells in vitro, but related in vivo studies are rare. This study aimed to investigate the role of lncRNA H19 in a nude mouse model of endometriosis. Ect...
ABSTRACT Objective The aim of the study was to assess the evidence on miRNAs as biomarkers for the diagnosis of endometriosis, as well as to provide insights into the challenges and strategies associated with the use of these molecules as accessible tools in clinical practice. Methods Systematic revi...
Abstract Objective To investigate the association between genetic polymorphisms in candidate genes or candidate regions and the development of endometriosis in Brazilian women. Methods A total of 30 women between 25 and 64 years old with a diagnosis of endometriosis participated in the present study, a...
SUMMARY OBJECTIVE: Ovarian endometriosis seriously affects the quality of life of females, and long non-coding RNA lncRNA urothelial carcinoma-associated 1 (UCA1) plays pivotal roles in the pathogenesis of various ovarian diseases. However, the involvement of lncRNA UCA1 in ovarian endometriosis remains...
Análisis de Varianza,
Biomarcadores/sangre,
Estudios de Casos y Controles,
Regulación hacia Abajo,
Endometriosis/sangre,
Endometriosis/diagnóstico,
Endometriosis/genética,
Endometrio/patología,
Enfermedades del Ovario/sangre,
Enfermedades del Ovario/diagnóstico,
Enfermedades del Ovario/genética,
Pronóstico Clínico Dinámico Homeopático,
ARN Largo no Codificante/sangre,
ARN Largo no Codificante/genética,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Recurrencia,
Valores de Referencia,
Sensibilidad y Especificidad
Abstract Objective The aim of the present study was to analyze the expression of the CD63, S100A6, and GNB2L1genes, which participate in mechanisms related to the complex pathophysiology of endometriosis. Methods A case-control study was conducted with 40 women who were diagnosed with endometriosis, ...
Apoptosis/genética,
Estudios de Casos y Controles,
Proteínas de Ciclo Celular/genética,
Proliferación Celular/genética,
Endometriosis/genética,
Endometriosis/patología,
Expresión Génica,
Proteínas de Neoplasias/genética,
Neovascularización Patológica/genética,
Receptores de Cinasa C Activada/genética,
Proteína A6 de Unión a Calcio de la Familia S100/genética,
Tetraspanina 30/genética
Abstract Objective The present study aims to investigate the association between caspase-8 (CASP8) (rs13416436 and rs2037815) and Fas cell surface death receptor (FAS) (rs3740286 and rs4064) polymorphisms with endometriosis in Brazilian women. Methods In the present case-control study, 45 women with ...
Abstract Purpose To evaluate the magnitude of the association of the polymorphisms of the genes PGR, CYP17A1 and CYP19A1 in the development of endometriosis. Methods This is a retrospective case-control study involving 161 women with endometriosis (cases) and 179 controls. The polymorphisms were geno...
ABSTRACT Objective To evaluate PTPN22 C1858T polymorphism and the risk of endometriosis. Methods A meta-analysis of 10 published case-control studies (from four articles), with a total sample of 971 cases and 1,181 controls, was performed. We estimated risk (odds ratio and 95% confidence intervals) o...
Endometriosis is a benign, estrogen-dependent disease with symptoms such as pelvic pain and infertility, and it is characterized by the ectopic distribution of endometrial tissue. The expression of the ID2, PRELP and SMOC2 genes was compared between the endometrium of women without endometriosis in the p...
Estudios de Casos y Controles,
Endometriosis/genética,
Endometriosis/metabolismo,
Proteínas de la Matriz Extracelular/genética,
Proteínas de la Matriz Extracelular/metabolismo,
Regulación de la Expresión Génica,
Glicoproteínas/genética,
Glicoproteínas/metabolismo,
Proteína 2 Inhibidora de la Diferenciación/genética,
Proteína 2 Inhibidora de la Diferenciación/metabolismo,
Ciclo Menstrual,
Osteonectina/genética,
Enfermedades Peritoneales/genética,
Reacción en Cadena en Tiempo Real de la Polimerasa
