Results: 6

Avaliação da infecção por Parvovírus Humano B19 em diferentes grupos populacionais: diagnóstico diferencial e aspectos imunopatogênicos da infecção aguda e persistente

Alves, Arthur Daniel Rocha.

A infecção pelo Parvovírus B19 (B19V) pode ocorrer em indivíduos imunocompetentes e imunocomprometidos, de todas as faixas etárias, e se caracteriza por ser aguda e autolimitada, podendo levar a quadros de doença exantemática (DE), doença febril aguda (DFA), doença renal crônica (DRC) e falênc...

Reacción en Cadena en Tiempo Real de la Polimerasa, Parvovirus B19 Humano, Infecciones, Diagnóstico Diferencial, Endonucleasas, Prueba de Laboratorio, Virión

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Evaluation of nuclear NF-κB, transglutaminase2, and ERCC1 as predictors of platinum resistance in testicular tumors

Azambuja, Alan A; Engroff, Paula; Silva, Bruna T; Zorzetti, Roberta C. S; Morrone, Fernanda B.

Int. braz. j. urol; 46 (3), 2020

ABSTRACT Purpose: Testicular germ cells tumor (TGCT) are associated with a high cure rate and are treated with platinum-based chemotherapy. However, a group of testicular cancer patients may have a very unfavorable evolution and insensitivity to the main therapeutic agent chemotherapy (CT) cisplatin. Th...

Protocolos de Quimioterapia Combinada Antineoplásica, Cisplatino, Reparación del ADN, Proteínas de Unión al ADN, Resistencia a Antineoplásicos/fisiología, Endonucleasas, Proteínas de Unión al GTP/metabolismo, Neoplasias Pulmonares, FN-kappa B/metabolismo, Pronóstico, Estudios Retrospectivos, Neoplasias Testiculares, Transglutaminasas/metabolismo

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Response to cytotoxic chemotherapy and overall survival in non-small cell lung cancer patients with positive or negative ERCC1 expression

Honma, Helen Naemi; Perroud Jr, Maurício Wesley; Morcillo, André Moreno; Vassallo, José; Zambon, Lair.

J. bras. pneumol; 44 (3), 2018

Antineoplásicos/uso terapéutico, Carcinoma de Pulmón de Células no Pequeñas/química, Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico, Carcinoma de Pulmón de Células no Pequeñas/mortalidad, Cisplatino/uso terapéutico, Proteínas de Unión al ADN/análisis, Endonucleasas/análisis, Inmunohistoquímica, Neoplasias Pulmonares/química, Neoplasias Pulmonares/tratamiento farmacológico, Neoplasias Pulmonares/mortalidad, Paclitaxel/uso terapéutico, Factores de Tiempo, Resultado del Tratamiento

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Relationship between the Asp1104His polymorphism of the nucleotide excision repair gene ERCC5 and treatment sensitivity to oxaliplatin in patients with advanced colorectal cancer in China

Kong, Jiangying; Liu, Zhuo; Cai, Feng; Xu, Xiaocheng; LiuI, Jun.

Clinics; 73 (), 2018

OBJECTIVES: To study the relationship between the Asp1104His polymorphism of the nucleotide excision repair gene ERCC5 and treatment sensitivity to oxaliplatin in patients with advanced colorectal cancer (CRC) in China. METHODS: A group of 226 patients in the Department of Gastrointestinal Oncology at Z...

Antineoplásicos/uso terapéutico, Estudios de Casos y Controles, Neoplasias Colorrectales/tratamiento farmacológico, Neoplasias Colorrectales/genética, Neoplasias Colorrectales/mortalidad, Proteínas de Unión al ADN/genética, Endonucleasas/genética, Genotipo, Estimación de Kaplan-Meier, Estadificación de Neoplasias, Proteínas Nucleares/genética, Oxaliplatino/uso terapéutico, Polimorfismo de Nucleótido Simple/genética, Factores de Transcripción/genética

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Radiotherapy modulates expression of EGFR, ERCC1 and p53 in cervical cancer

de Almeida, V H; de Melo, A C; Meira, D D; Pires, A C; Nogueira-Rodrigues, A; Pimenta-Inada, H K; Alves, F G; Moralez, G; Thiago, L S; Ferreira, C G; Sternberg, C.

Braz. j. med. biol. res; 51 (1), 2018

Cervical cancer is a public health problem and the molecular mechanisms underlying radioresistance are still poorly understood. Here, we evaluated the modulation of key molecules involved in cell proliferation, cell cycle and DNA repair in cervical cancer cell lines (CASKI and C33A) and in malignant tiss...

Western Blotting, Carcinoma de Células Escamosas/genética, Carcinoma de Células Escamosas/patología, Carcinoma de Células Escamosas/radioterapia, Línea Celular Tumoral, Proteínas de Unión al ADN/efectos de la radiación, Endonucleasas/efectos de la radiación, Genes erbB-1/efectos de la radiación, Genes p53/efectos de la radiación, Inmunohistoquímica, Estudios Prospectivos, Neoplasias del Cuello Uterino/radioterapia, Ensayo de Tumor de Célula Madre, Mutación

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Enzyme activity and thermostability of a non-specific nuclease from Yersinia enterocolitica subsp. palearctica by site-directed mutagenesis

Zhang, Yu; Li, Zhen-Hua; Zheng, Wei; Tang, Zhen-Xing; Zhang, Zhi-Liang; Shi, Lu-E.

Electron. j. biotechnol; 19 (6), 2016

Background: To identify the critical amino acid residues that contribute to the high enzyme activity and good thermostability of Yersinia enterocolitica subsp. palearctica (Y. NSN), 15 mutants of Y. NSN were obtained by site-directed mutagenesis in this study. And their enzyme activity and thermostabilit...

Yersinia enterocolitica/enzimología, Estabilidad de Enzimas, Pruebas de Enzimas, Calor, Mutagénesis Sitio-Dirigida, Desoxirribonucleasas/química, Desoxirribonucleasas/genética, Endonucleasas/química, Endonucleasas/genética

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