LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Relationship between the Asp1104His polymorphism of the nucleotide excision repair gene ERCC5 and treatment sensitivity to oxaliplatin in patients with advanced colorectal cancer in China

Kong, Jiangying; Liu, Zhuo; Cai, Feng; Xu, Xiaocheng; LiuI, Jun.

Clinics; 73 (), 2018

OBJECTIVES: To study the relationship between the Asp1104His polymorphism of the nucleotide excision repair gene ERCC5 and treatment sensitivity to oxaliplatin in patients with advanced colorectal cancer (CRC) in China. METHODS: A group of 226 patients in the Department of Gastrointestinal Oncology at Z...

Antineoplásicos/uso terapéutico, Estudios de Casos y Controles, Neoplasias Colorrectales/tratamiento farmacológico, Neoplasias Colorrectales/genética, Neoplasias Colorrectales/mortalidad, Proteínas de Unión al ADN/genética, Endonucleasas/genética, Genotipo, Estimación de Kaplan-Meier, Estadificación de Neoplasias, Proteínas Nucleares/genética, Oxaliplatino/uso terapéutico, Polimorfismo de Nucleótido Simple/genética, Factores de Transcripción/genética

Fulltext

Enzyme activity and thermostability of a non-specific nuclease from Yersinia enterocolitica subsp. palearctica by site-directed mutagenesis

Background: To identify the critical amino acid residues that contribute to the high enzyme activity and good thermostability of Yersinia enterocolitica subsp. palearctica (Y. NSN), 15 mutants of Y. NSN were obtained by site-directed mutagenesis in this study. And their enzyme activity and thermostabilit...