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Inhibition of miR-383 suppresses oxidative stress and improves endothelial function by increasing sirtuin 1

Hu, Baoxiang; Gong, Zushun; Bi, Zhaohui.
Braz. j. med. biol. res; 53 (2), 2020
Previous research has shown that suppression of miR-383 can prevent inflammation of the endothelium, as well as postpone the development of atherosclerosis. However, the role of miR-383 in endothelial cell apoptosis in diabetes remains unclear. The aim of this study was to investigate the function of miR...
Apoptosis/efectos de los fármacos, Células Cultivadas, Endotelio Vascular/citología, Endotelio Vascular/efectos de los fármacos, Endotelio Vascular/fisiología, Glucosa/farmacología, Ratones Endogámicos C57BL, MicroARNs/antagonistas & inhibidores, Estrés Oxidativo/efectos de los fármacos, Transducción de Señal, Sirtuina 1/metabolismo
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Involvement of endothelial CK2 in the radiation induced perivascular resistant niche (PVRN) and the induction of radioresistance for non-small cell lung cancer (NSCLC) cells

Li, Qianwen; Zong, Yan; Li, Ke; Jie, Xiaohua; Hong, Jiaxin; Zhou, Xiaoshu; Wu, Bian; Li, Zhenyu; Zhang, Sheng; Wu, Gang; Meng, Rui.
Biol. Res; 52 (), 2019
BACKGROUND: Tumor microenvironment (TME) plays a vital role in determining the outcomes of radiotherapy. As an important component of TME, vascular endothelial cells are involved in the perivascular resistance niche (PVRN), which is formed by inflammation or cytokine production induced by ionizing radiat...
Carcinoma de Pulmón de Células no Pequeñas/radioterapia, Quinasa de la Caseína II/antagonistas & inhibidores, Células Endoteliales/efectos de la radiación, Neoplasias Pulmonares/tratamiento farmacológico, Inhibidores de Proteínas Quinasas/farmacología, Antraquinonas/farmacología, Citocinas/biosíntesis, Endotelio Vascular/citología, Naftiridinas/farmacología, Western Blotting
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