Results: 17

Efectos del reto de líquidos sobre el acople ventrículo arterial en un biomodelo porcino de choque endotóxico

Repert. med. cir; 33 (2), 2024
Introducción: el reto de líquidos es una prueba que consiste en administrarlos y medir la respuesta hemodinámica mediante el cambio del gasto cardíaco (GC), aunque solo medir el GC resulta insuficiente. El acople ventrículo-arterial (AVA) (elastancia arterial efectiva/ elastancia telesistólica: Eae...

Sildenafil in endotoxin-induced pulmonary hypertension: an experimental study

Braz. J. Anesth. (Impr.); 73 (4), 2023
Abstract Background Sepsis and septic shock still represent great challenges in critical care medicine. Sildenafil has been largely used in the treatment of pulmonary arterial hypertension, but its effects in sepsis are unknown. The aim of this study was to investigate the hypothesis that sildenafil can...

Correction: Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis

Biol. Res; 56 (), 2023

Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis

Biol. Res; 56 (), 2023
BACKGROUND: Sepsis is an uncontrolled inflammatory response against a systemic infection that results in elevated mortality, mainly induced by bacterial products known as endotoxins, producing endotoxemia. Disseminated intravascular coagulation (DIC) is frequently observed in septic patients and is assoc...

Efeito da ingestão de suco de uva sobre a expressão de microRNA no plasma e em células mononucleares em mulheres com sobrepeso

Introdução: O padrão da dieta ocidental, caracterizado pela ingestão elevada de açúcares e lipídios, está relacionado à gênese da inflamação metabólica, a qual é caracterizada por um quadro de inflamação crônica, sistêmica e de baixa intensidade. A inflamação metabólica contribui par...

Recuperando el “hilo perdido” en la madeja de la enterocolitis necrotizante del recién nacido

Rev. ecuat. pediatr; 22 (2), 2021
Propósito de la revisión: el objetivo de la revisión es delinear la fisiopatología de la Entero Colitis Necrotizante (ECN) clásica del recién nacido, proponer un listado de antecedentes perinatales que definan un grupo de riesgo y establecer parámetros simples y objetivos, que ayuden a establecer...

Study of thermo-regulation as a worsening marker of experimental sepsis in an animal model

Objective: to analyze variations in body temperature and in plasma nitrate and lactate concentrations in rats submitted to the experimental sepsis model. Method: a total of 40 rats divided equally into five groups. The induction of endotoxemia was performed with intravenous administration of lipopolys...

Protective effect of dexmedetomidine against organ dysfunction in a two-hit model of hemorrhage/resuscitation and endotoxemia in rats

Braz. j. med. biol. res; 52 (3), 2019
Dexmedetomidine (DEX), a selective agonist of α2-adrenergic receptors, has anti-inflammation properties and potential beneficial effects against trauma, shock, or infection. Therefore, this study aimed to investigate whether DEX might protect against multiple-organ dysfunction in a two-hit model of ...

Laminar lesions in horses with systemic oxidative stress, committed by experimentally induced or naturally occurring gastrointestinal disorders

Pesqui. vet. bras; 36 (8), 2016
Laminitis in horses can be associated with lesions in multiple organs secondary to sepsis. Twenty-one horses suffering from gastrointestinal disorders were used in the experiment; 7 horses with experimentally induced endotoxemia and intestinal ischaemia, and 14 horses suffering from naturally occurring c...

Microbiota e barreira intestinal: implicações para obesidade
Microbiota and intestinal barrier: implications for obesity

Clin. biomed. res; 36 (4), 2016
A epidemia da obesidade é considerada um importante problema de saúde pública na sociedade ocidental, pois ela se relaciona a comorbidades como síndrome metabólica, diabetes mellitus e hipertensão. A microbiota intestinal pode contribuir para o desenvolvimento da obesidade através do aumento da ex...