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Quercetin and resveratrol are associated with the downregulation of TNFalpha/NF-kB/inos axis-mediated acute liver injury in rats induced by paracetamol poisoning

Alqahtani, Saeed M; Dawood, Amal F; Kamar, Samaa S; Haidara, Mohamed A; ShamsEldeen, Asmaa M; Dallak, Mohammad; Al-Ani, Bahjat; Ebrahim, Hasnaa A.
Int. j. morphol; 41 (1), 2023
SUMMARY: Paracetamol (known as acetaminophen, or APAP) poisoning causes acute liver damage that can lead to organ failure and death. We sought to determine that APAP overdose can augment tumor necrosis factor-alpha (TNF-α)/ nuclear factor kappa B (NF-kB)/induced nitic oxide synthase (iNOS) axis-medi...
Enfermedad Hepática Crónica Inducida por Sustancias y Drogas/tratamiento farmacológico, Acetaminofén/toxicidad, Quercetina/administración & dosificación, Resveratrol/administración & dosificación, Enfermedad Aguda, Factor de Necrosis Tumoral alfa/antagonistas & inhibidores, FN-kappa B/antagonistas & inhibidores, Óxido Nítrico Sintasa/antagonistas & inhibidores, Quimioterapia Combinada, Sobredosis de Droga, Ratas Sprague-Dawley, Sustancias Protectoras
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Vitamin C administration attenuated artemether induced hepatic injury in rats

Eid, Refaat A; Zaki, Mohamed Samir Ahmed; Alghamdi, Mansour A; Sideeg, Abulqasim Mohammed; Ali, Kamal, Z. M; Andarawi, Mohamed; Haidara, Mohamed A.
Int. j. morphol; 38 (1), 2020
This research was designed to investigate the potential protective effect of vitamin C supplementation against hepatocyte ultrastructural alterations induced by artemether (antimalarial drug) administration. Twenty-four adult male albino rats were used in this study and were divided into four groups (n=6...
Ácido Ascórbico/administración & dosificación, Ácido Ascórbico/farmacología, Enfermedad Hepática Crónica Inducida por Sustancias y Drogas/tratamiento farmacológico, Arteméter/toxicidad, Estrés Oxidativo/efectos de los fármacos, Biomarcadores, Hepatocitos/ultraestructura, Modelos Animales de Enfermedad, Ratas Sprague-Dawley, Superóxido Dismutasa/análisis, Glutatión Peroxidasa/análisis, Microscopía Electrónica de Transmisión, Enfermedad Hepática Inducida por Sustancias y Drogas/patología, Hepatocitos/efectos de los fármacos, Medicamentos Hepatoprotectores
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