Results: 599

Aducanumab: una mirada dos años después de su aprobación

Biomédica (Bogotá); 44 (supl.1), 2024
Alzheimer’s disease is the leading cause of dementia worldwide and a critical public health problem. While deaths from cardiovascular diseases have decreased, those attributed to Alzheimer’s disease have increased in recent years with no curative treatment to date. In this context, effective treatmen...

Relação entre a doença periodontal e a doença de Alzheimer - Revisão da Literatura

O objetivo do presente estudo foi revisar a literatura para buscar evidências na associação entre a doença de Alzheimer e a Periodontite. A metodologia usada resultou numa busca às bases de dados PubMed/MEDLINE, Cochrane Library e Web of Science, através dos artigos publicados entre o período de m...

Effects of physical exercise on cognition and glymphatic system of patients with mild cognitive impairment or Alzheimer’s disease – study protocol

Geriatr Gerontol Aging; 18 (), 2024
Objective: To evaluate the impact of a multicomponent physical exercise program on clinical variables associated with the glymphatic clearance system, sleep-awake patterns, and cognitive function in individuals with mild cognitive impairment or mild Alzheimer’s disease. Methods: This is a single-center...

Factores de riesgo y biomarcadores de la enfermedad de Alzheimer
Risk factors and biomarkers of Alzheimer's disease

Rev. cuba. med. mil; 53 (1), 2024
Introducción: La enfermedad de Alzheimer, constituye un problema sanitario y social de gran magnitud; precisa de diagnóstico y terapéutica precoces. Se realizó una búsqueda de artículos sobre factores de riesgo y biomarcadores de la enfermedad en las bases de datos PubMed/Medline, Scopus, Scielo y ...

New candidate SNPs for genetic association with Alzheimer’s disease: a linkage disequilibrium analysis for the FCGRIIB and PILRA genes

Medwave; 24 (1), 2024
BACKGROUND: Two new SNPs have been recently associated to Alzheimer’s disease in African American populations: FCGRIIB rs1050501 C/T, and PILRA rs1859788 A/G. The risk of Alzheimer’s disease in FCGRIIB C and PILRA A allele carriers is three times higher than in non-carriers. However, the association ...

Rational drug repurposing for alzheimer's treatment using in-silico ligand and structure-based approaches

Abstract Alzheimer's disease is a devastating neurodegenerative disorder characterized by memory loss and cognitive decline. New AD treatments are essential, and drug repositioning is a promising approach. In this study, we combined ligand-based and structure-based approaches to identify potential candid...

Cuidados paliativos à pessoa idosa com Doença de Alzheimer

REVISA (Online); 13 (2), 2024
Objetivo: Realizar uma revisão integrativa da literatura sobre o acesso aos cuidados paliativos por idosos com Doença de Alzheimer. Método:Trata-se de uma revisão integrativa utilizando os descritores “doença de Alzheimer”, “cuidados paliativos” e “idoso” realizada nas...

Qualidade de vida do cuidador informal de idosos com doença de alzheimer na pandemia COVID-19

Rev Enferm UFPI; 12 (1), 2023
Objetivo: Desvelar sobre a qualidade de vida dos cuidadores informais de idosos com Doença de Alzheimer em tempos de pandemia da COVID-19. Método: Estudo descritivo, qualitativo, por meio de entrevista semiestruturada com 12 cuidadores informais de idosos, selecionados por conveniênci...

Quantitative and qualitative analysis of neuroinflammation by beta amyloid1-42 toxin after treatment with resveratrol-loaded nanoparticles

Background: This study evaluated the effects of zein nanoparticles with resveratrol on neuroinflammation caused by Alzheimer’s disease. Method: The sample consisted of 30 animals divided into control (C), positive control (CP), white nanoparticles (NB), resveratrol nanoparticles (NR) and resveratrol (R...

Relación de la enfermedad periodontal inflamatoria crónica con enfermedades sistémicas
Relationship of chronic inflammatory periodontal disease with systemic diseases

Rev. cuba. med. mil; 52 (4), 2023
Introducción: La enfermedad periodontal es una infección inmunoinflamatoria crónica de origen multifactorial. Puede avanzar a nivel sistémico por el paso de bacterias y sus productos al torrente sanguíneo, lo cual constituye un factor de riesgo para alteraciones sistémicas. La revisión bibliográf...