Results: 31

Las orexinas como biomarcadores para demencia tipo Alzheimer y relación con síntomas neuropsiquiátricos

RESUMEN: Los biomarcadores más estudiados en la demencia tipo Alzheimer (DA) son los niveles elevados de Aβ42 y de proteína Tau en líquido cefalorraquídeo. Dada la complejidad de la sintomatología cognitiva y síntomas neuropsiquiátricos (SNP) de esta patología, algunos estudios recientes pro...

Disfunción inmunológica en enfermedad de Alzheimer; proinflamatoria en etapas iniciales y regulatoria, y exhausta en etapas avanzadas
Immune dysfunction in disease Alzheimer's; proinflammatory in stages initial and regulatory, and exhaustive in advanced stages

Alzheimer disease (AD) is the main cause of dementia worldwide and a source of important population morbidity and mortality. It is estimate that its prevalence will increase dramatically in the upcoming years. The classical clinical presentation of AD is an amnesic hippocampal syndrome, and Mild Cognitiv...

Os impactos da neuroinflamação na doença de Alzheimer

Clin. biomed. res; 42 (4), 2022
A Doença de Alzheimer (DA) consiste em um grande problema de saúde pública no Brasil e no mundo. Trata-se de uma doença neurodegenerativa, em que ocorre perda progressiva de neurônios e atrofia das regiões cerebrais. Essa degeneração está associada principalmente ao depósito de duas proteínas ...

Avaliação do Impacto do Nível Educacional na Doença de Alzheimer: Artigo Original

A doença de Alzheimer (DA) consiste em uma doença neurodegenerativa progressiva, irreversível e de aparecimento insidioso. O grau de escolaridade formal, assim como a reserva cognitiva, vem sendo proposto como fator protetor da DA, interagindo com a predisposição genética na gênese e curso evoluti...

Impacto de las emociones sobre la memoria declarativa en la enfermedad de Alzheimer

Esta investigación tuvo como objetivo determinar la influencia de las emociones en los procesos de memoria declarativa en personas con enfermedad de Alzheimer. Para esto, se planteó un estudio con diseño comparativo-correlacional y modelo no probabilístico. Participaron 160 adultos mayores, 80 con di...

Alzheimer's disease and sleep disturbances: a review

Arq. neuropsiquiatr; 77 (11), 2019
ABSTRACT The association between Alzheimer's disease (AD) and sleep disturbances has received increasing scientific attention in the last decades. However, little is known about the impact of sleep and its disturbances on the development of preclinical AD stages, such as mild cognitive impairment. This r...

Decreased plasmatic spermidine and increased spermine in mild cognitive impairment and Alzheimer's disease patients

Abstract Background Current evidence suggests that upregulation of polyamines system plays a role both in cognitive deficit and synaptic loss observed in Alzheimer's disease (AD). Objective The aim of this study was to determine the plasmatic concentration of polyamines in mild cognitive impairment (...

Exploratory analysis of rare and novel variants in Mexican patients diagnosed with schizophrenia and dementia

Rev. invest. clín; 71 (4), 2019
Abstract Background Schizophrenia (SCZ) and dementia, often related, are two of the most common neuropsychiatric diseases; epidemiological studies have shown that SCZ patients present a 2-fold increased risk for dementia compared to non-schizophrenic individuals. We explored the presence of rare and nov...

Evaluación neuropsicológica de la memoria semántica en demencia presenil y declive cognitivo atípico: ¿estamos preparados?

El envejecimiento de la población es un fenómeno demográfico de preocupación mundial. Junto al aumento de la población mayor, aumenta también el número de enfermedades neurodegenerativas. La enfermedad de Alzheimer y la demencia frontotemporal, son las principales causas del envejecimiento cogniti...

Nutritional and hematological factors associated with the progression of Alzheimer's disease: a cohort study

SUMMARY OBJECTIVE: We studied the users of the Specialized Drug Distribution Program of the public health network. METHODS: A prospective cohort examined the elderly at two intervals of three years and included 30 patients in phase I and 16 in phase II. The methodology was composed of home visits, anth...