Abstract Alzheimer's disease is a devastating neurodegenerative disorder characterized by memory loss and cognitive decline. New AD treatments are essential, and drug repositioning is a promising approach. In this study, we combined ligand-based and structure-based approaches to identify potential candid...
Abstract Donepezil-HCl is a member of the acetylcholinesterase inhibitors that is indicated for the symptomatic treatment of Alzheimer’s disease (AD) and has many side effects. In this study, to reduce the side effects of Donepezil-HCl and increase the penetration of the drug through the blood-brain ba...
Abstract Due to the fact that different isoforms of carbonic anhydrase play distinct physiological roles, their diseases/disorders involvement are different as well. Involvement in major disorders such as glaucoma, epilepsy, Alzheimer's disease, obesity and cancers, have turned carbonic anhydrase into a ...
Abstract To assess the therapy relative to indication, effectiveness, safety and adherence in patients with Alzheimer’s disease (AD). An interventional, prospective, non-randomized study was conducted in a single secondary care center in Brazil. The pharmacist-led medication therapy management (MTM) wa...
A Doença de Alzheimer (DA) é a principal forma de demência e um dos grandes desafios no sistema de saúde do século 21. O Comprometimento Cognitvo Leve (CCL) é um estágio que antecede a DA e que compartilha algumas vias metabólicas em comum. A fisiopatologia da DA é caracterizada pela ampla morte...
Estado Nutricional/genética,
Disfunción Cognitiva/patología,
Enfermedad de Alzheimer/patología,
Selenio/análisis,
Disfunción Cognitiva/diagnóstico,
Personas/clasificación,
Apolipoproteína E4/agonistas,
Selenoproteína P/efectos adversos,
Factor Neurotrófico Derivado del Encéfalo/agonistas,
Factores de Crecimiento Nervioso/efectos adversos,
d0072490
The hypotheses currently considered the most likely causes of Alzheimer's disease (AD) are amyloid beta peptide deposition in the cerebral cortex and hyperphosphorylation of the Tau protein, with the consequent formation of neurofibrillary tangles. In clinical practice, although not accurate, AD diagnosi...
Oral fast-dispersible film was prepared by utlizing donepezil hydrochloride (drug) and various cellulose derivatives such as hydroxypropyl methyl cellulose (hypermellose) (HPMC), microcrystalline cellulose (MCC) and nanocrystalline cellulose (NCC) to treat Alzheimer's disease. NCC was synthesized by ultr...
RESUMO Pesquisas recentes demonstram que o hipocampo apresenta uma redução de volume no final da idade adulta, mantendo uma estreita relação com o declínio cognitivo. A aquisição da imagem por diversos métodos de medição de volume nos leva a encontrar na ressonância magnética o método de des...
ABSTRACT Cell physiology is impaired before protein aggregation and this may be more relevant than inclusions themselves for neurodegeneration. The present study aimed to characterize an animal model to enable the analysis of the cell biology before and after protein aggregation. Ten-month-old Lewis rats...
Enfermedad de Alzheimer/metabolismo,
Enfermedad de Alzheimer/patología,
Péptidos beta-Amiloides/efectos de los fármacos,
Péptidos beta-Amiloides/metabolismo,
Western Blotting,
Sistema Nervioso Central/efectos de los fármacos,
Sistema Nervioso Central/metabolismo,
Sistema Nervioso Central/patología,
Modelos Animales de Enfermedad,
Hipocampo/efectos de los fármacos,
Hipocampo/metabolismo,
Hipocampo/patología,
Inmunohistoquímica,
Agregación Patológica de Proteínas/inducido químicamente,
Agregación Patológica de Proteínas/patología,
Rotenona/administración & dosificación,
Sustancia Negra/efectos de los fármacos,
alfa-Sinucleína/efectos de los fármacos,
alfa-Sinucleína/metabolismo,
Ratas Endogámicas Lew,
Reproducibilidad de los Resultados,
Estrés Oxidativo
Introdução: a doença de Alzheimer é a demência mais prevalente na prática clínica da enfermagem. Esta patologia caracteriza-se pela presença de placas amielóides e emaranhados neurofibrilares no cérebro, bem como diminuição geral do cérebro e do número de neurônios. Objetivo: elencar a pro...
