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Circulating miR-146a as a possible candidate biomarker in the indeterminate phase of Chagas disease

Ballinas-Verdugo, Martha Alicia; Jiménez-Ortega, Rogelio Frank; Martínez-Martínez, Eduardo; Rivas, Nancy; Contreras-López, Erick Abraham; Carbó, Roxana; Sánchez, Fausto; Bojalil, Rafael; Márquez-Velasco, Ricardo; Sánchez-Muñoz, Fausto; Alejandre-Aguilar, Ricardo.
Biol. Res; 54 (), 2021
BACKGROUND: Chagas disease is considered important and presents intense inflammatory and fibrotic processes induced by the perpetuation of the parasite in the affected tissues and organs. Therefore, it is necessary to inquire about the host defense and attack mechanisms to have a more detailed knowledge ...
Enfermedad de Chagas/genética, MicroARNs/genética, Biomarcadores, Biología Computacional, Fibrosis
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Influence of Angiotensin-converting Enzyme Insertion/Deletion Gene Polymorphism in Progression of Chagas Heart Disease

Alves, Silvia Marinho Martins; Alvarado-Arnês, Lúcia Elena; Cavalcanti, Maria da Glória Aureliano de Melo; Carrazzone, Cristina de Fátima Velloso; Pacheco, Antônio Guilherme Fonseca; Sarteschi, Camila; Moraes, Milton Ozorio; Oliveira Junior, Wilson Alves de; Medeiros, Carolina de Araújo; Pessoa, Fernanda Gallinaro; Mady, Charles; Lannes-Vieira, Joseli; Ramires, Felix José Alvarez.
Rev. Soc. Bras. Med. Trop; 53 (), 2020
Abstract INTRODUCTION: Chagas disease (CD) is a neglected disease caused by the parasite Trypanosoma cruzi. One-third of infected patients will develop the cardiac form, which may progress to heart failure (HF). However, the factors that determine disease progression remain unclear. Increased angiotens...
Inhibidores de la Enzima Convertidora de Angiotensina, Brasil, Estudios de Casos y Controles, Enfermedad de Chagas/genética, Enfermedad de Chagas/fisiopatología, Estudios de Cohortes, Progresión de la Enfermedad, Genotipo, Insuficiencia Cardíaca/genética, Insuficiencia Cardíaca/fisiopatología, Persona de Mediana Edad, Peptidil-Dipeptidasa A/genética, Polimorfismo Genético/genética
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Preliminary study between Y chromosome haplogroups and chagasic cardiomyopathy manifestations in patients with Chagas disease

Lassen, Oscar; Tabares, Sandra; Bertolotto, Patricia; Ojeda, Silvia; Sembaj, Adela.
Rev. Soc. Bras. Med. Trop; 53 (), 2020
Abstract INTRODUCTION: Among patients with Chagas disease, men have a higher risk of worse pathological symptoms than women. We aimed to explore the role of the Y chromosome in men diagnosed with Chagas disease and assess the relationship between their ancestry and disease status. METHODS In this comp...
Cardiomiopatías, Enfermedad de Chagas/complicaciones, Enfermedad de Chagas/genética, Cromosomas Humanos Y/genética, Haplotipos, Oportunidad Relativa
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Association of vitamin D3, VDR gene polymorphisms, and LL-37 with a clinical form of Chagas Disease

Oliveira Junior, Luiz Roberto de; Carvalho, Thaysa Buss; Santos, Rodrigo Mattos dos; Costa, Érika Alessandra Pellison Nunes da; Pereira, Paulo Câmara Marques; Kurokawa, Cilmery Suemi.
Rev. Soc. Bras. Med. Trop; 52 (), 2019
Abstract INTRODUCTION: Chagas disease (CD) is an important public health problem in Brazil and worldwide. Aging and obesity are important matters in patients with CD, as is hypovitaminosis D3, which can decrease the quality of life of these patients. Immunomodulation mediated by vitamin D3, especially ...
Péptidos Catiónicos Antimicrobianos/sangre, Biomarcadores/sangre, Enfermedad de Chagas/sangre, Enfermedad de Chagas/genética, Colecalciferol/sangre, Persona de Mediana Edad, Polimorfismo Genético/genética, Receptores de Calcitriol/genética
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