Exploring redox vulnerabilities in JAK2V617F-positive cellular models
Hematol., Transfus. Cell Ther. (Impr.); 43 (4), 2021
ABSTRACT Background: In Philadelphia chromosome-negative myeloproliferative neoplasm (MPN) models, reactive oxygen species (ROS) are elevated and have been implicated in genomic instability, JAK2/STAT signaling amplification, and disease progression. Although the potential effects of ROS on the MPN phen...