Home > LILACS - Literatura Latinoamericana y del Caribe de Ciencias de la Salud > Search result

Results: 3

Rational drug repurposing for alzheimer's treatment using in-silico ligand and structure-based approaches

Rathi, Karishma; Wavhale, Ravindra; Bhole, Ritesh; Undale, Vaishali; Chaudhari, Somdatta.
Braz. J. Pharm. Sci. (Online); 60 (), 2024
Abstract Alzheimer's disease is a devastating neurodegenerative disorder characterized by memory loss and cognitive decline. New AD treatments are essential, and drug repositioning is a promising approach. In this study, we combined ligand-based and structure-based approaches to identify potential candid...
Preparaciones Farmacéuticas/clasificación, Enfermedad de Alzheimer/patología, Reposicionamiento de Medicamentos/clasificación, Donepezilo/agonistas, Enfermedades Neurodegenerativas/clasificación, d0105990, Preparaciones Farmacéuticas/análisis
Fulltext

Efeito de aldeídos de colesterol na esclerose lateral amiotrófica: estudo em modelo animal e na agregação da SOD1 in vitro

Dantas, Lucas Souza.
Aldeídos de colesterol (Secosterol A e Secosterol B) têm sido detectados em amostras de cérebro humano e investigados em modelos de doenças neurodegenerativas como possíveis marcadores e intermediários do processo patológico. Estes oxisteróis constituem uma classe de eletrófilos derivados de lip...
Aldehídos/análisis, Superóxido Dismutasa-1/farmacología, Enfermedades Neurodegenerativas/clasificación, Colesterol/análisis, Esclerosis Amiotrófica Lateral/patología
Fulltext

Evaluation of the effect of natural peptide 'Urocortin' on corticotrophin releasing factor (CRF) receptor expression in ND7/23 cells

Mohiuddin, Omair Anwar; Biggs, Chris.
Braz. j. pharm. sci; 51 (1), 2015
CRF receptors are involved in the stress management of the cells and are believed to have a cytoprotective role in the body. CRF receptors have been reported to be potential drug targets for the treatment of neurodegenerative disorders. The cell line used in the study is ND7/23 (mouse neuroblastoma and r...
Hormona Adrenocorticotrópica/farmacocinética, Urocortinas/análisis, Enfermedades Neurodegenerativas/clasificación, Neuroblastoma
Fulltext