Complex proteinopathies and neurodegeneration: insights from the study of transmissible spongiform encephalopathies
Arq. neuropsiquiatr; 76 (10), 2018
ABSTRACT Protein misfolding diseases are usually associated with deposits of single "key" proteins that somehow drive the pathology; β-amyloid and hyperphosphorylated tau accumulate in Alzheimer's disease, α-synuclein in Parkinson's disease, or abnormal prion protein (PrPTSE) in transmissible s...