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Modified comet assay with Giemsa staining: a suitable method for assessing genotoxicity in rats

Fagian, M. A. B; Fluminhan, A; Araújo, E; Reis, L. S. L. S.
Arq. bras. med. vet. zootec. (Online); 72 (3), 2020
The present study tested a comet assay that was modified for compatibility with Giemsa staining to assess the drug genotoxicity in the peripheral blood of rats. We analysed the peripheral blood of 16 female Wistar rats (N=8 rats/group) from a control group and from a group that was treated with an intrap...
Coloración y Etiquetado/veterinaria, Ensayo Cometa/veterinaria, Genotoxicidad/análisis, Electroforesis/veterinaria, Pruebas de Mutagenicidad/veterinaria, Colorantes Azulados/toxicidad
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Cadmium-induced apoptosis of Siberian tiger fibroblasts via disrupted intracellular homeostasis

Wang, Hui; Liu, Zheng; Zhang, Wenxiu; Yuan, Ziao; Yuan, Hongyi; Liu, Xueting; Yang, Chunwen; Guan, Weijun.
Biol. Res; 49 (), 2016
BACKGROUND: Heavy metals can cause great harm to Siberian tigers in the natural environment. Cadmium (Cd2+) is an environmental contaminant that affects multiple cellular processes, including cell proliferation, differentiation, and survival. It has been shown to induce apoptosis in a variety of cell typ...
Apoptosis/efectos de los fármacos, Cadmio/toxicidad, Fibroblastos/efectos de los fármacos, Homeostasis/efectos de los fármacos, Espacio Intracelular/efectos de los fármacos, Tigres, Apoptosis/genética, Caspasas/análisis, Caspasas/efectos de los fármacos, Ciclo Celular/efectos de los fármacos, Ensayo Cometa/veterinaria, Fibroblastos/fisiología, Homeostasis/fisiología, Potencial de la Membrana Mitocondrial/efectos de los fármacos, Especies Reactivas de Oxígeno/análisis, Células Cultivadas, Daño del ADN, Microscopía Electrónica de Transmisión, Reacción en Cadena de la Polimerasa, Transcripción Reversa, Siberia
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